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Tmem9 transmembrane protein 9 [ Mus musculus (house mouse) ]

Gene ID: 66241, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem9provided by MGI
Official Full Name
transmembrane protein 9provided by MGI
Primary source
MGI:MGI:1913491
See related
Ensembl:ENSMUSG00000026411 AllianceGenome:MGI:1913491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500015G18Rik
Summary
Involved in positive regulation of canonical Wnt signaling pathway and regulation of protein catabolic process. Predicted to be located in bounding membrane of organelle; intercellular bridge; and mitotic spindle. Is expressed in central nervous system; retina; and tooth. Orthologous to human TMEM9 (transmembrane protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 68.3), kidney adult (RPKM 56.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 59.51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135935957..135962768)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136008219..136035030)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene troponin T2, cardiac Neighboring gene STARR-seq mESC enhancer starr_02397 Neighboring gene plakophilin 1 Neighboring gene immunoglobulin-like and fibronectin type III domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02398 Neighboring gene STARR-seq mESC enhancer starr_02399 Neighboring gene STARR-positive B cell enhancer ABC_E10039 Neighboring gene STARR-positive B cell enhancer ABC_E4348 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_02400

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes. Kveine M, et al. Biochem Biophys Res Commun, 2002 Oct 4. PMID 12359240
  2. TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. Jung YS, et al. Hepatology, 2021 Feb. PMID 32380568, Free PMC Article
  3. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Jung YS, et al. Nat Cell Biol, 2018 Dec. PMID 30374053, Free PMC Article
  4. p57Kip2 expression is enhanced during mid-cardiac murine development and is restricted to trabecular myocardium. Kochilas LK, et al. Pediatr Res, 1999 May. PMID 10231856
  5. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Van Dyck F, et al. Cell Metab, 2007 Nov. PMID 17983586

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM9-v-ATPase Activates Wnt/beta-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
    Title: TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton-transporting V-type ATPase complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
proton-transporting V-type ATPase complex assembly regulator TMEM9
Names
v-ATPase assembly regulator TMEM9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160145.1 → NP_001153617.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

    See identical proteins and their annotated locations for NP_001153617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AC108813, AC124375, BQ918002
    Consensus CDS
    CCDS15323.1
    UniProtKB/Swiss-Prot
    Q3U459, Q9CR23
    Related
    ENSMUSP00000128185.2, ENSMUST00000165125.8
    Conserved Domains (1) summary
    pfam05434
    Location:44 → 182
    Tmemb_9; TMEM9

  2. NM_001160146.1 → NP_001153618.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

    See identical proteins and their annotated locations for NP_001153618.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC108813, AC124375, CX208138
    Consensus CDS
    CCDS15323.1
    UniProtKB/Swiss-Prot
    Q3U459, Q9CR23
    Related
    ENSMUSP00000113416.2, ENSMUST00000117950.2
    Conserved Domains (1) summary
    pfam05434
    Location:44 → 182
    Tmemb_9; TMEM9

  3. NM_025439.3 → NP_079715.1  proton-transporting V-type ATPase complex assembly regulator TMEM9 precursor

    See identical proteins and their annotated locations for NP_079715.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AC108813, AC124375, CA460035
    Consensus CDS
    CCDS15323.1
    UniProtKB/Swiss-Prot
    Q3U459, Q9CR23
    Related
    ENSMUSP00000065409.9, ENSMUST00000063719.15
    Conserved Domains (1) summary
    pfam05434
    Location:44 → 182
    Tmemb_9; TMEM9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135935957..135962768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR23.1 GenPept UniProtKB/Swiss-Prot:Q9CR23

Gene LinkOut

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