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Rpl3l ribosomal protein L3-like [ Mus musculus (house mouse) ]

Gene ID: 66211, updated on 11-Apr-2024

Summary

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Official Symbol
Rpl3lprovided by MGI
Official Full Name
ribosomal protein L3-likeprovided by MGI
Primary source
MGI:MGI:1913461
See related
Ensembl:ENSMUSG00000002500 AllianceGenome:MGI:1913461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110057H16Rik
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in ribosomal large subunit assembly. Predicted to be part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human RPL3L (ribosomal protein L3 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 33.5), mammary gland adult (RPKM 7.6) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 12.52 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24946800..24955117)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24727826..24736143)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 64 Neighboring gene ribosomal protein S2 Neighboring gene STARR-positive B cell enhancer ABC_E1936 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function. Shiraishi C, et al. Nat Commun, 2023 Apr 20. PMID 37080962, Free PMC Article
  2. Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart. Milenkovic I, et al. Nucleic Acids Res, 2023 Jun 23. PMID 36882085, Free PMC Article
  3. Rpl3l gene deletion in mice reduces heart weight over time. Grimes KM, et al. Front Physiol, 2023. PMID 36733907, Free PMC Article
  4. Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice. Kao BR, et al. Nucleic Acid Ther, 2021 Dec. PMID 34081545
  5. Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth. Chaillou T, et al. J Cell Physiol, 2016 Sep. PMID 26684695, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach.
    Title: Exploring the Regulation and Function of Rpl3l in the Development of Early-Onset Dilated Cardiomyopathy and Congestive Heart Failure Using Systems Genetics Approach.
  2. Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
    Title: Dynamic interplay between RPL3- and RPL3L-containing ribosomes modulates mitochondrial activity in the mammalian heart.
  3. RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.
    Title: RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.
  4. Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.
    Title: Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of myotube differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of striated muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL3-like
Names
60S ribosomal protein L3-like
ribosomal protein L3 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163945.2 → NP_001157417.1  large ribosomal subunit protein uL3-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC154566
    Consensus CDS
    CCDS50019.1
    UniProtKB/Swiss-Prot
    E9PWZ3, Q5U470, Q9CQ09
    Related
    ENSMUSP00000129325.2, ENSMUST00000170239.9
    Conserved Domains (2) summary
    PTZ00103
    Location:1 → 400
    PTZ00103; 60S ribosomal protein L3; Provisional
    cl00324
    Location:7 → 373
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

  2. NM_025425.5 → NP_079701.1  large ribosomal subunit protein uL3-like isoform 2

    See identical proteins and their annotated locations for NP_079701.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR, lacks some 5' coding region segments, and uses a downstream AUG codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC154566
    Consensus CDS
    CCDS37494.1
    UniProtKB/TrEMBL
    Q9CQ09
    Related
    ENSMUSP00000038326.9, ENSMUST00000045186.11
    Conserved Domains (1) summary
    cl00324
    Location:9 → 206
    RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24946800..24955117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249982.2 → XP_030105842.1  large ribosomal subunit protein uL3-like isoform X1

    Conserved Domains (1) summary
    PTZ00103
    Location:1 → 348
    PTZ00103; 60S ribosomal protein L3; Provisional

  2. XM_017317609.3 → XP_017173098.1  large ribosomal subunit protein uL3-like isoform X1

    Conserved Domains (1) summary
    PTZ00103
    Location:1 → 348
    PTZ00103; 60S ribosomal protein L3; Provisional

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_019796.1: Suppressed sequence

    Description
    NG_019796.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PWZ3.1 GenPept UniProtKB/Swiss-Prot:E9PWZ3

Gene LinkOut

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