Commd6 COMM domain containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Commd6provided by MGI
Official Full Name: COMM domain containing 6provided by MGI
Primary source: MGI:MGI:1913450
See related: Ensembl:ENSMUSG00000075486 AllianceGenome:MGI:1913450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110059J08Rik; 1700063H17Rik
Summary: Predicted to enable NF-kappaB binding activity. Predicted to be involved in negative regulation of NF-kappaB transcription factor activity. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human COMMD6 (COMM domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 15.4), placenta adult (RPKM 14.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E2.3; 14 50.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (101871202..101877907, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (101633766..101640471, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134357 (e-PCR)
- UniSTS:217639

NoName (e-PCR)
- UniSTS:237239

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	IBA Inferred from Biological aspect of Ancestor more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COMM domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033132.3 → NP_001028304.1 COMM domain-containing protein 6 isoform 1

See identical proteins and their annotated locations for NP_001028304.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

BB577089, BC132261, CK128085

Consensus CDS

CCDS37000.1

UniProtKB/Swiss-Prot

Q3V4B5

UniProtKB/TrEMBL

B7ZNP2

Related

ENSMUSP00000097912.3, ENSMUST00000100339.9

Conserved Domains (1) summary

cl06336
Location:8 → 85

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
NM_001168592.1 → NP_001162064.1 COMM domain-containing protein 6 isoform 2

See identical proteins and their annotated locations for NP_001162064.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

BB577089, CK128085, CK621880

Consensus CDS

CCDS49557.1

UniProtKB/TrEMBL

B7ZNP3

Related

ENSMUSP00000131634.2, ENSMUST00000168587.3

Conserved Domains (1) summary

cl06336
Location:8 → 81

Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...