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Mrpl4 mitochondrial ribosomal protein L4 [ Mus musculus (house mouse) ]

Gene ID: 66163, updated on 11-Apr-2024

Summary

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Official Symbol
Mrpl4provided by MGI
Official Full Name
mitochondrial ribosomal protein L4provided by MGI
Primary source
MGI:MGI:2137210
See related
Ensembl:ENSMUSG00000003299 AllianceGenome:MGI:2137210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110017G11Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; liver; pancreas epithelium; and submandibular gland primordium. Orthologous to human MRPL4 (mitochondrial ribosomal protein L4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 78.0), kidney adult (RPKM 50.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.69 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20907040..20920135)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21001252..21008839)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 1 Neighboring gene microRNA 7081 Neighboring gene STARR-seq mESC enhancer starr_23470 Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene STARR-seq mESC enhancer starr_23474 Neighboring gene STARR-seq mESC enhancer starr_23475 Neighboring gene STARR-seq mESC enhancer starr_23476 Neighboring gene intercellular adhesion molecule 1 Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Liu HB, et al. Adv Sci (Weinh), 2019 Aug 7. PMID 31406667, Free PMC Article
  2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
  3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL4m
Names
39S ribosomal protein L4, mitochondrial
L4mt
MRP-L4
NP_001344828.1
NP_075656.2
XP_006510603.1
XP_036011066.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357899.1 → NP_001344828.1  large ribosomal subunit protein uL4m isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159314
    UniProtKB/TrEMBL
    A0A1L1SSY9
    Related
    ENSMUSP00000150112.2, ENSMUST00000214124.2
    Conserved Domains (1) summary
    pfam00573
    Location:81 → 278
    Ribosomal_L4; Ribosomal protein L4/L1 family

  2. NM_023167.2 → NP_075656.2  large ribosomal subunit protein uL4m isoform 2

    See identical proteins and their annotated locations for NP_075656.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC159314, AK002464, BC051685
    Consensus CDS
    CCDS40548.1
    UniProtKB/Swiss-Prot
    Q811L8, Q8JZU9, Q9DCU6, Q9JJB3
    UniProtKB/TrEMBL
    A0A1L1SSY9
    Related
    ENSMUSP00000003386.6, ENSMUST00000003386.7
    Conserved Domains (1) summary
    pfam00573
    Location:81 → 272
    Ribosomal_L4; Ribosomal protein L4/L1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20907040..20920135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510540.3 → XP_006510603.1  large ribosomal subunit protein uL4m isoform X1

    UniProtKB/TrEMBL
    A0A1L1SSY9
    Conserved Domains (1) summary
    pfam00573
    Location:81 → 266
    Ribosomal_L4; Ribosomal protein L4/L1 family

  2. XM_036155173.1 → XP_036011066.1  large ribosomal subunit protein uL4m isoform X2

    Conserved Domains (1) summary
    pfam00573
    Location:66 → 189
    Ribosomal_L4; Ribosomal protein L4/L1 family

RNA

  1. XR_003947968.2 RNA Sequence

  2. XR_379129.3 RNA Sequence

  3. XR_001778962.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCU6.1 GenPept UniProtKB/Swiss-Prot:Q9DCU6

Gene LinkOut

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