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Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X [ Mus musculus (house mouse) ]

Gene ID: 66152, updated on 5-Mar-2024

Summary

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Official Symbol
Uqcr10provided by MGI
Official Full Name
ubiquinol-cytochrome c reductase, complex III subunit Xprovided by MGI
Primary source
MGI:MGI:1913402
See related
Ensembl:ENSMUSG00000059534 AllianceGenome:MGI:1913402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ucrc; 1110020P15Rik
Summary
Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human UQCR10 (ubiquinol-cytochrome c reductase, complex III subunit X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 398.9), heart adult (RPKM 307.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 2.96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4651968..4654344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4701968..4704344, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11961 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene activating signal cointegrator 1 complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_28397 Neighboring gene STARR-seq mESC enhancer starr_28398 Neighboring gene STARR-positive B cell enhancer ABC_E2979 Neighboring gene zinc finger, matrin type 5 Neighboring gene STARR-seq mESC enhancer starr_28401 Neighboring gene calcium binding protein 7 Neighboring gene predicted gene, 35102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Schilling B, et al. Biochim Biophys Acta, 2006 Feb. PMID 16120479
  2. Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice. Inoue M, et al. Endocrinology, 2016 Mar. PMID 26697723
  3. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
  4. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
  5. Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2). Guo R, et al. Cell, 2017 Sep 7. PMID 28844695

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome b-c1 complex subunit 9
Names
complex III subunit 9
complex III subunit X
cytochrome c1 non-heme 7 kDa protein
ubiquinol-cytochrome c reductase complex (7.2 kD)
ubiquinol-cytochrome c reductase complex 7.2 kDa protein
ubiquinol-cytochrome c reductase complex protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362879.1 → NP_001349808.1  cytochrome b-c1 complex subunit 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606521
    Conserved Domains (1) summary
    pfam05365
    Location:10 → 54
    UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like

  2. NM_197979.3 → NP_932096.1  cytochrome b-c1 complex subunit 9 isoform 1

    See identical proteins and their annotated locations for NP_932096.1

    Status: VALIDATED

    Source sequence(s)
    AW985484, BC100591, CB599515
    Consensus CDS
    CCDS36098.1
    UniProtKB/Swiss-Prot
    Q8R1I1
    UniProtKB/TrEMBL
    Q5NCJ9
    Related
    ENSMUSP00000054856.5, ENSMUST00000058407.6
    Conserved Domains (1) summary
    pfam05365
    Location:10 → 60
    UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like

RNA

  1. NR_156411.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606521, AU258939
    Related
    ENSMUST00000151559.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4651968..4654344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047158.1: Suppressed sequence

    Description
    NM_001047158.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1I1.1 GenPept UniProtKB/Swiss-Prot:Q8R1I1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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