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Prorp protein only RNase P catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 66132, updated on 21-Apr-2024

Summary

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Official Symbol
Prorpprovided by MGI
Official Full Name
protein only RNase P catalytic subunitprovided by MGI
Primary source
MGI:MGI:1913382
See related
Ensembl:ENSMUSG00000021023 AllianceGenome:MGI:1913382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrpp3; mKIAA0391; 1110008L16Rik
Summary
Predicted to enable ribonuclease P activity. Predicted to be involved in mitochondrial tRNA 5'-end processing and tRNA 5'-leader removal. Located in mitochondrial nucleoid. Orthologous to human PRORP (protein only RNase P catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.8), bladder adult (RPKM 2.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C1; 12 23.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55349422..55429276)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55302637..55382492)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member A2 Neighboring gene STARR-positive B cell enhancer mm9_chr12:56329932-56330232 Neighboring gene predicted gene 2446 Neighboring gene signal recognition particle 54C Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene STARR-positive B cell enhancer ABC_E3052 Neighboring gene STARR-positive B cell enhancer ABC_E3053 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56490469-56490652 Neighboring gene STARR-positive B cell enhancer ABC_E8483 Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene proteasome subunit alpha 6 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Simultaneous processing and degradation of mitochondrial RNAs revealed by circularized RNA sequencing. Kuznetsova I, et al. Nucleic Acids Res, 2017 May 19. PMID 28201688, Free PMC Article
  2. Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly. Rackham O, et al. Cell Rep, 2016 Aug 16. PMID 27498866
  3. Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Bogenhagen DF, et al. Cell Metab, 2014 Apr 1. PMID 24703694
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0391

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA 5'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 5'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial ribonuclease P catalytic subunit
Names
mitochondrial RNase P protein 3
mitochondrial ribonuclease P protein 3
NP_079649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025373.1 → NP_079649.1  mitochondrial ribonuclease P catalytic subunit precursor

    See identical proteins and their annotated locations for NP_079649.1

    Status: VALIDATED

    Source sequence(s)
    AK031144, AK151976, AV233350
    Consensus CDS
    CCDS49068.1
    UniProtKB/Swiss-Prot
    Q6A076, Q8BSN8, Q8JZY4, Q9CTH1, Q9D7W9
    UniProtKB/TrEMBL
    V9GXP4
    Related
    ENSMUSP00000021411.8, ENSMUST00000021411.15
    Conserved Domains (2) summary
    sd00004
    Location:171 → 201
    PPR; PPR repeat [structural motif]
    pfam16953
    Location:339 → 575
    PRORP; Protein-only RNase P

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    55349422..55429276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZY4.1 GenPept UniProtKB/Swiss-Prot:Q8JZY4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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