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Tipin timeless interacting protein [ Mus musculus (house mouse) ]

Gene ID: 66131, updated on 5-Mar-2024

Summary

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Official Symbol
Tipinprovided by MGI
Official Full Name
timeless interacting proteinprovided by MGI
Primary source
MGI:MGI:1921571
See related
Ensembl:ENSMUSG00000032397 AllianceGenome:MGI:1921571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110005A05Rik; 1110018P21Rik
Summary
The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
Expression
Biased expression in liver E14 (RPKM 28.2), CNS E11.5 (RPKM 20.3) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 C; 9 34.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64188776..64212704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64281491..64305422)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8856 Neighboring gene STARR-positive B cell enhancer ABC_E2293 Neighboring gene STARR-seq mESC enhancer starr_24425 Neighboring gene STARR-seq mESC enhancer starr_24427 Neighboring gene STARR-positive B cell enhancer ABC_E6754 Neighboring gene ubiquitin carboxyl-terminal esterase L4 Neighboring gene STARR-seq mESC enhancer starr_24428 Neighboring gene predicted gene, 24289 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene STARR-seq mESC enhancer starr_24432 Neighboring gene STARR-seq mESC enhancer starr_24433 Neighboring gene multiple EGF-like-domains 11 Neighboring gene STARR-seq mESC enhancer starr_24435 Neighboring gene STARR-positive B cell enhancer mm9_chr9:64519558-64519858 Neighboring gene predicted gene, 36311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice. Howden R, et al. Am J Respir Cell Mol Biol, 2012 Apr. PMID 22052878, Free PMC Article
  2. Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. Smith KD, et al. J Cell Biol, 2009 Oct 5. PMID 19805627, Free PMC Article
  3. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. Gotter AL. J Mol Biol, 2003 Aug 1. PMID 12875843
  4. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. Gotter AL, et al. J Mol Biol, 2007 Feb 9. PMID 17141802, Free PMC Article
  5. CUL2(LRR1) , TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. Villa F, et al. EMBO Rep, 2021 Mar 3. PMID 33590678, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
    Title: Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
  2. mTIM promotes the nuclear localization of TIPIN, and TIPIN is capable of regulating mTIM activity by disrupting the ability of mTIM to form homo-multimeric complexes
    Title: Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association.
  3. TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs.
    Title: Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TIMELESS-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324556.1 → NP_001311485.1  TIMELESS-interacting protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK038111, BF463598, CJ082457
    Consensus CDS
    CCDS23279.1
    UniProtKB/Swiss-Prot
    Q91WA1, Q9CQM3, Q9D1J4
    Conserved Domains (1) summary
    pfam07962
    Location:63 → 145
    Swi3; Replication Fork Protection Component Swi3

  2. NM_001324557.1 → NP_001311486.1  TIMELESS-interacting protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK011357, AK038111, CJ082457
    Consensus CDS
    CCDS23279.1
    UniProtKB/Swiss-Prot
    Q91WA1, Q9CQM3, Q9D1J4
    Conserved Domains (1) summary
    pfam07962
    Location:63 → 145
    Swi3; Replication Fork Protection Component Swi3

  3. NM_001324558.1 → NP_001311487.1  TIMELESS-interacting protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK038111, CJ082457
    Consensus CDS
    CCDS23279.1
    UniProtKB/Swiss-Prot
    Q91WA1, Q9CQM3, Q9D1J4
    Related
    ENSMUSP00000149833.2, ENSMUST00000216594.2
    Conserved Domains (1) summary
    pfam07962
    Location:63 → 145
    Swi3; Replication Fork Protection Component Swi3

  4. NM_025372.4 → NP_079648.1  TIMELESS-interacting protein

    See identical proteins and their annotated locations for NP_079648.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK003802, AK038111, CJ082457
    Consensus CDS
    CCDS23279.1
    UniProtKB/Swiss-Prot
    Q91WA1, Q9CQM3, Q9D1J4
    Related
    ENSMUSP00000034964.7, ENSMUST00000034964.7
    Conserved Domains (1) summary
    pfam07962
    Location:63 → 145
    Swi3; Replication Fork Protection Component Swi3

RNA

  1. NR_136926.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK038111, CA321902, CJ082457

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64188776..64212704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244490.2 → XP_030100350.1  TIMELESS-interacting protein isoform X2

    Conserved Domains (1) summary
    pfam07962
    Location:1 → 42
    Swi3; Replication Fork Protection Component Swi3

  2. XM_030244491.2 → XP_030100351.1  TIMELESS-interacting protein isoform X2

    Conserved Domains (1) summary
    pfam07962
    Location:1 → 42
    Swi3; Replication Fork Protection Component Swi3

  3. XM_030244489.2 → XP_030100349.1  TIMELESS-interacting protein isoform X2

    Conserved Domains (1) summary
    pfam07962
    Location:1 → 42
    Swi3; Replication Fork Protection Component Swi3

  4. XM_006511340.4 → XP_006511403.1  TIMELESS-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006511403.1

    UniProtKB/Swiss-Prot
    Q91WA1, Q9CQM3, Q9D1J4
    Conserved Domains (1) summary
    pfam07962
    Location:63 → 145
    Swi3; Replication Fork Protection Component Swi3

RNA

  1. XR_003947967.2 RNA Sequence

  2. XR_003947966.2 RNA Sequence

  3. XR_001778960.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WA1.2 GenPept UniProtKB/Swiss-Prot:Q91WA1

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