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Josd2 Josephin domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 66124, updated on 5-Mar-2024

Summary

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Official Symbol
Josd2provided by MGI
Official Full Name
Josephin domain containing 2provided by MGI
Primary source
MGI:MGI:1913374
See related
Ensembl:ENSMUSG00000038695 AllianceGenome:MGI:1913374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110007C05Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Is expressed in heart and node. Orthologous to human JOSD2 (Josephin domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 55.3), liver E14 (RPKM 49.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.83 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44117404..44121082)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44467980..44471658)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003 Neighboring gene STARR-positive B cell enhancer ABC_E9110 Neighboring gene aspartate dehydrogenase domain containing Neighboring gene microRNA 7052 Neighboring gene RIKEN cDNA 5430431A17 gene Neighboring gene STARR-seq mESC enhancer starr_18800 Neighboring gene ER membrane protein complex subunit 10 Neighboring gene golgi associated RAB2 interactor 5A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural modeling of ataxin-3 reveals distant homology to adaptins. Albrecht M, et al. Proteins, 2003 Feb 1. PMID 12486728
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
josephin-2
Names
josephin domain-containing protein 2
NP_001191999.1
NP_001192000.1
NP_001192001.1
NP_001192002.1
NP_001347533.1
NP_079644.1
XP_006541134.1
XP_006541135.1
XP_030098747.1
XP_036009235.1
XP_036009236.1
XP_036009237.1
XP_036009238.1
XP_036009239.1
XP_036009240.1
XP_036009241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205070.1 → NP_001191999.1  josephin-2 isoform a

    See identical proteins and their annotated locations for NP_001191999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 3, 4 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC149607
    Consensus CDS
    CCDS21208.1
    UniProtKB/Swiss-Prot
    Q9CR30
    Related
    ENSMUSP00000113226.2, ENSMUST00000118493.8
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  2. NM_001205071.1 → NP_001192000.1  josephin-2 isoform a

    See identical proteins and their annotated locations for NP_001192000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC149607
    Consensus CDS
    CCDS21208.1
    UniProtKB/Swiss-Prot
    Q9CR30
    Related
    ENSMUSP00000113172.2, ENSMUST00000118628.8
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  3. NM_001205072.1 → NP_001192001.1  josephin-2 isoform a

    See identical proteins and their annotated locations for NP_001192001.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC149607, AK002872
    Consensus CDS
    CCDS21208.1
    UniProtKB/Swiss-Prot
    Q9CR30
    Related
    ENSMUSP00000113313.2, ENSMUST00000117324.8
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  4. NM_001205073.1 → NP_001192002.1  josephin-2 isoform a

    See identical proteins and their annotated locations for NP_001192002.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC149607, CA326008
    Consensus CDS
    CCDS21208.1
    UniProtKB/Swiss-Prot
    Q9CR30
    Related
    ENSMUSP00000114105.2, ENSMUST00000120852.8
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  5. NM_001360604.1 → NP_001347533.1  josephin-2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC149607, BY230733
    Consensus CDS
    CCDS90222.1
    UniProtKB/TrEMBL
    D3YTZ7
    Related
    ENSMUSP00000112796.2, ENSMUST00000121922.3
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 124
    Josephin

  6. NM_025368.4 → NP_079644.1  josephin-2 isoform a

    See identical proteins and their annotated locations for NP_079644.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC149607, AK003525, AV011743
    Consensus CDS
    CCDS21208.1
    UniProtKB/Swiss-Prot
    Q9CR30
    Related
    ENSMUSP00000048415.5, ENSMUST00000035844.11
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

RNA

  1. NR_153758.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC149607, CX201137

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44117404..44121082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153343.1 → XP_036009236.1  josephin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CR30
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  2. XM_030242887.1 → XP_030098747.1  josephin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CR30
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  3. XM_006541072.3 → XP_006541135.1  josephin-2 isoform X2

    Conserved Domains (1) summary
    pfam02099
    Location:57 → 204
    Josephin

  4. XM_036153344.1 → XP_036009237.1  josephin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CR30
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  5. XM_036153348.1 → XP_036009241.1  josephin-2 isoform X5

    UniProtKB/TrEMBL
    D3YTZ7
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 124
    Josephin

  6. XM_006541071.3 → XP_006541134.1  josephin-2 isoform X1

    Conserved Domains (1) summary
    pfam02099
    Location:58 → 205
    Josephin

  7. XM_036153346.1 → XP_036009239.1  josephin-2 isoform X4

    Conserved Domains (1) summary
    pfam02099
    Location:58 → 163
    Josephin

  8. XM_036153345.1 → XP_036009238.1  josephin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CR30
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin

  9. XM_036153347.1 → XP_036009240.1  josephin-2 isoform X5

    UniProtKB/TrEMBL
    D3YTZ7
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 124
    Josephin

  10. XM_036153342.1 → XP_036009235.1  josephin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q9CR30
    Conserved Domains (1) summary
    pfam02099
    Location:19 → 166
    Josephin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR30.1 GenPept UniProtKB/Swiss-Prot:Q9CR30

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