Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufa9provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit A9provided by MGI
Primary source: MGI:MGI:1913358
See related: Ensembl:ENSMUSG00000000399 AllianceGenome:MGI:1913358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1010001N11Rik
Summary: Predicted to enable NADH dehydrogenase activity. Predicted to be involved in circadian rhythm; mitochondrial respiratory chain complex I assembly; and ubiquinone-6 biosynthetic process. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 197.9), kidney adult (RPKM 121.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 61.92 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (126798826..126826107, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (126821863..126849144, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndufa9 (e-PCR), detects polymorphism
- UniSTS:527438

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADH dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed
involved_in ubiquinone-6 biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in respirasome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Names: CI-39kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9; NADH-ubiquinone oxidoreductase 39 kDa subunit; complex I-39kD

NP_079634.2

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025358.3 → NP_079634.2 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor

See identical proteins and their annotated locations for NP_079634.2

Status: VALIDATED

Source sequence(s)

AC165085, AK012366

Consensus CDS

CCDS20557.1

UniProtKB/Swiss-Prot

Q6GTD3, Q99JP9, Q9DC69

UniProtKB/TrEMBL

A0A0R3P9C8

Related

ENSMUSP00000144904.2, ENSMUST00000205002.3

Conserved Domains (1) summary

cd05271
Location:54 → 326

NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs