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Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 66098, updated on 5-Mar-2024

Summary

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Official Symbol
Chchd6provided by MGI
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 6provided by MGI
Primary source
MGI:MGI:1913348
See related
Ensembl:ENSMUSG00000030086 AllianceGenome:MGI:1913348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Micos25; 0710001P09Rik; 1700021B03Rik
Summary
Predicted to be involved in cellular response to DNA damage stimulus and cristae formation. Predicted to be located in cytosol and mitochondrial inner membrane. Predicted to be part of MICOS complex. Predicted to be active in mitochondrion. Orthologous to human CHCHD6 (coiled-coil-helix-coiled-coil-helix domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 117.1), CNS E18 (RPKM 34.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 D1; 6 39.91 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (89360128..89572634, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (89383146..89595652, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930512J16 gene Neighboring gene STARR-seq mESC enhancer starr_16595 Neighboring gene STARR-seq mESC enhancer starr_16597 Neighboring gene predicted gene, 36735 Neighboring gene STARR-positive B cell enhancer ABC_E10391 Neighboring gene STARR-seq mESC enhancer starr_16599 Neighboring gene STARR-seq mESC enhancer starr_16600 Neighboring gene plexin A1 Neighboring gene predicted gene, 52910 Neighboring gene predicted gene, 46966 Neighboring gene STARR-seq mESC enhancer starr_16603 Neighboring gene predicted gene, 19896 Neighboring gene 40S ribosomal protein S17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease. Shang Y, et al. Acta Neuropathol, 2022 Nov. PMID 36104602, Free PMC Article
  2. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
  3. RNA binding proteins co-localize with small tau inclusions in tauopathy. Maziuk BF, et al. Acta Neuropathol Commun, 2018 Aug 1. PMID 30068389, Free PMC Article
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
    Title: A CHCHD6-APP axis connects amyloid and mitochondrial pathology in Alzheimer's disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in cristae formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cristae formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MICOS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MICOS complex subunit Mic25
Names
coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167736.1 → NP_001161208.1  MICOS complex subunit Mic25 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK015314, BQ177996, BY278681
    Consensus CDS
    CCDS51846.1
    UniProtKB/TrEMBL
    E9Q4M4, Q9DA45
    Related
    ENSMUSP00000109179.4, ENSMUST00000113550.6
    Conserved Domains (2) summary
    pfam05300
    Location:17 → 199
    DUF737; Protein of unknown function (DUF737)
    pfam06747
    Location:207 → 240
    CHCH; CHCH domain

  2. NM_025351.3 → NP_079627.3  MICOS complex subunit Mic25 isoform 1

    See identical proteins and their annotated locations for NP_079627.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK015314, BY278681
    Consensus CDS
    CCDS39557.1
    UniProtKB/Swiss-Prot
    Q3UNQ1, Q91VN4, Q9D5I5, Q9DAM8
    UniProtKB/TrEMBL
    Q9DA45
    Related
    ENSMUSP00000032172.9, ENSMUST00000032172.14
    Conserved Domains (2) summary
    pfam05300
    Location:17 → 227
    DUF737; Protein of unknown function (DUF737)
    pfam06747
    Location:235 → 268
    CHCH; CHCH domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    89360128..89572634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VN4.2 GenPept UniProtKB/Swiss-Prot:Q91VN4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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