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Rmnd5b required for meiotic nuclear division 5 homolog B [ Mus musculus (house mouse) ]

Gene ID: 66089, updated on 11-Apr-2024

Summary

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Official Symbol
Rmnd5bprovided by MGI
Official Full Name
required for meiotic nuclear division 5 homolog Bprovided by MGI
Primary source
MGI:MGI:1913339
See related
Ensembl:ENSMUSG00000001054 AllianceGenome:MGI:1913339
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gid2; 0610039K22Rik
Summary
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of GID complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human RMND5B (required for meiotic nuclear division 5 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 67.7), adrenal adult (RPKM 44.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 31.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51514500..51526723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51623673..51635896, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene STARR-positive B cell enhancer mm9_chr11:51347850-51348150 Neighboring gene STARR-positive B cell enhancer ABC_E6980 Neighboring gene STARR-seq mESC enhancer starr_29416 Neighboring gene STARR-positive B cell enhancer ABC_E3947 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene STARR-positive B cell enhancer ABC_E255 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene STARR-positive B cell enhancer ABC_E8400 Neighboring gene STARR-seq mESC enhancer starr_29422 Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene NHP2 ribonucleoprotein Neighboring gene predicted gene, 30058 Neighboring gene NEDD4 binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein transferase RMND5B
Names
protein RMD5 homolog B
NP_079622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025346.1 → NP_079622.1  E3 ubiquitin-protein transferase RMND5B

    See identical proteins and their annotated locations for NP_079622.1

    Status: PROVISIONAL

    Source sequence(s)
    AK075599
    Consensus CDS
    CCDS24656.1
    UniProtKB/Swiss-Prot
    Q91YQ7
    Related
    ENSMUSP00000001081.4, ENSMUST00000001081.10
    Conserved Domains (5) summary
    smart00667
    Location:116 → 148
    LisH; Lissencephaly type-1-like homology motif
    smart00668
    Location:156 → 212
    CTLH; C-terminal to LisH motif
    smart00757
    Location:210 → 304
    CRA; CT11-RanBPM
    pfam10607
    Location:155 → 299
    CLTH; CTLH/CRA C-terminal to LisH motif domain
    pfam13445
    Location:338 → 377
    zf-RING_UBOX; RING-type zinc-finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    51514500..51526723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YQ7.1 GenPept UniProtKB/Swiss-Prot:Q91YQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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