Cep20 centrosomal protein 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep20provided by MGI
Official Full Name: centrosomal protein 20provided by MGI
Primary source: MGI:MGI:1913336
See related: Ensembl:ENSMUSG00000022677 AllianceGenome:MGI:1913336
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fopnl; 0610037P05Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly. Predicted to act upstream of or within cell projection organization. Located in ciliary basal body and motile cilium. Is expressed in cerebral cortex subventricular zone and cortical plate. Orthologous to human CEP20 (centrosomal protein 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 10.8), genital fat pad adult (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 9.74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (14117105..14136093, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (14299241..14318229, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggested that the centrosomal protein FOR20 is a new member of the microtubule-associated protein family and that it regulates the assembly and dynamics of microtubules while interacting with tubulin.
Title: A centrosomal protein FOR20 regulates microtubule assembly dynamics and plays a role in cell migration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in microtubule anchoring	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
is_active_in motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein 20

Names: FGFR1OP N-terminal-like protein; FOP-related protein of 20 kDa; Fgfr1op N-terminal like; lisH domain-containing protein C16orf63 homolog; lisH domain-containing protein FOPNL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025345.2 → NP_079621.1 centrosomal protein 20

See identical proteins and their annotated locations for NP_079621.1

Status: PROVISIONAL

Source sequence(s)

BC011300

Consensus CDS

CCDS27973.1

UniProtKB/Swiss-Prot

Q3UIK2, Q9CZS3

Related

ENSMUSP00000023357.8, ENSMUST00000023357.14

Conserved Domains (1) summary

pfam09398
Location:43 → 113

FOP_dimer; FOP N terminal dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

14117105..14136093 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522450.4 → XP_006522513.1 centrosomal protein 20 isoform X1

Conserved Domains (1) summary

cl29685
Location:3 → 47

LisH_2
XM_017317110.2 → XP_017172599.1 centrosomal protein 20 isoform X2

Conserved Domains (1) summary

cl29685
Location:43 → 98

LisH_2