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Abhd6 abhydrolase domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 66082, updated on 21-Apr-2024

Summary

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Official Symbol
Abhd6provided by MGI
Official Full Name
abhydrolase domain containing 6provided by MGI
Primary source
MGI:MGI:1913332
See related
Ensembl:ENSMUSG00000025277 AllianceGenome:MGI:1913332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610041D24Rik
Summary
Enables acylglycerol lipase activity and phospholipase activity. Involved in several processes, including monoacylglycerol catabolic process; negative regulation of cold-induced thermogenesis; and phospholipid metabolic process. Acts upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Located in late endosome membrane; lysosomal membrane; and mitochondrion. Is integral component of postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol lipase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 11.3), large intestine adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 4.69 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14413000..14466885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8002888..8056773)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene PX domain containing serine/threonine kinase Neighboring gene STARR-positive B cell enhancer mm9_chr14:8946918-8947218 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene ribonuclease P 14 subunit Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene STARR-seq mESC enhancer starr_35858 Neighboring gene STARR-seq mESC enhancer starr_35854 Neighboring gene STARR-positive B cell enhancer ABC_E9890 Neighboring gene predicted gene, 30244 Neighboring gene deoxyribonuclease 1-like 3 Neighboring gene predicted gene 45521

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome. Westenbroek R, et al. Neurobiol Dis, 2023 May. PMID 36990366, Free PMC Article
  2. ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB(1) Receptors. Deng L, et al. Cannabis Cannabinoid Res, 2022 Apr. PMID 34705543, Free PMC Article
  3. Adipose ABHD6 regulates tolerance to cold and thermogenic programs. Poursharifi P, et al. JCI Insight, 2020 Dec 17. PMID 33201859, Free PMC Article
  4. Identification of α,β-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells. van Esbroeck ACM, et al. Front Mol Neurosci, 2019. PMID 31849602, Free PMC Article
  5. α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility. Fisette A, et al. Cell Rep, 2016 Oct 25. PMID 27783937

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility.
    Title: ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility.
  2. ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice.
    Title: ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol/PPAR signaling in obese mice.
  3. The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome.
    Title: The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome.
  4. Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.
    Title: Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status.
  5. Adipose ABHD6 regulates tolerance to cold and thermogenic programs.
    Title: Adipose ABHD6 regulates tolerance to cold and thermogenic programs.
  6. These findings identify ABHD6 as a regulator of the counter-regulatory responses to major metabolic shifts.
    Title: α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility.
  7. alpha/beta-domain hydrolase-6 suppression averts diet-induced obesity and enhances adipose browning and brown adipose function via PPAR alpha/PPAR gamma activation.
    Title: α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes.
  8. Whole-body and b-cell specific ABHD6-KO mice exhibit enhanced glucose-stimulated insulin secretion, and their islets show elevated monoacylglycerol production and insulin secretion in response to glucose.
    Title: α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.
  9. ABHD6 can hydrolyze several lipid substrates, positioning ABHD6 at the interface of glycerophospholipid metabolism and lipid signal transduction.
    Title: The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
  10. Data suggest ABHD6 as a therapeutic target that could be relevant in treating inflammation-related conditions.
    Title: Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylglycerol lipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acylglycerol lipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acylglycerol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acylglycerol catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysobisphosphatidic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of endocannabinoid signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
monoacylglycerol lipase ABHD6
Names
2-arachidonoylglycerol hydrolase
NP_001317993.1
NP_001317994.1
NP_079617.2
XP_006518136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331064.1 → NP_001317993.1  monoacylglycerol lipase ABHD6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC139029, AK076105, AK168782, BE624233, BQ176347
    Consensus CDS
    CCDS26808.1
    UniProtKB/Swiss-Prot
    Q3TGD2, Q8R2Y0, Q9DCD4
    Conserved Domains (1) summary
    COG0596
    Location:51 → 327
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. NM_001331065.1 → NP_001317994.1  monoacylglycerol lipase ABHD6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC139029, AK168782, BQ176347
    Consensus CDS
    CCDS88563.1
    UniProtKB/TrEMBL
    Q9D375
    Related
    ENSMUSP00000153068.2, ENSMUST00000225234.2

  3. NM_025341.4 → NP_079617.2  monoacylglycerol lipase ABHD6 isoform 1

    See identical proteins and their annotated locations for NP_079617.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA261636, AC139029, AK168782, BQ176347, BY253400, CX239001
    Consensus CDS
    CCDS26808.1
    UniProtKB/Swiss-Prot
    Q3TGD2, Q8R2Y0, Q9DCD4
    Related
    ENSMUSP00000129169.2, ENSMUST00000166497.9
    Conserved Domains (1) summary
    COG0596
    Location:51 → 327
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14413000..14466885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518073.4 → XP_006518136.1  monoacylglycerol lipase ABHD6 isoform X1

    See identical proteins and their annotated locations for XP_006518136.1

    UniProtKB/Swiss-Prot
    Q3TGD2, Q8R2Y0, Q9DCD4
    Conserved Domains (1) summary
    COG0596
    Location:51 → 327
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2Y0.1 GenPept UniProtKB/Swiss-Prot:Q8R2Y0

Gene LinkOut

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