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Aurkaip1 aurora kinase A interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 66077, updated on 5-Mar-2024

Summary

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Official Symbol
Aurkaip1provided by MGI
Official Full Name
aurora kinase A interacting protein 1provided by MGI
Primary source
MGI:MGI:1913327
See related
Ensembl:ENSMUSG00000065990 AllianceGenome:MGI:1913327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aip; Akip; MRP-S38; 0610033H09Rik
Summary
Predicted to be involved in mRNA processing. Predicted to act upstream of or within positive regulation of proteolysis. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human AURKAIP1 (aurora kinase A interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 84.4), duodenum adult (RPKM 60.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 87.55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155915709..155917555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155831269..155833098)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L20 Neighboring gene STARR-positive B cell enhancer ABC_E3560 Neighboring gene cyclin L2 Neighboring gene STARR-seq mESC enhancer starr_12275 Neighboring gene STARR-positive B cell enhancer ABC_E4740 Neighboring gene STARR-positive B cell enhancer ABC_E8042 Neighboring gene STARR-positive B cell enhancer ABC_E10297 Neighboring gene matrix-remodelling associated 8 Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Lim SK, et al. Biochem J, 2007 Apr 1. PMID 17125467, Free PMC Article
  2. Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase. Kiat LS, et al. J Biol Chem, 2002 Nov 22. PMID 12244051
  3. Positional cloning of the mouse saccharin preference (Sac) locus. Bachmanov AA, et al. Chem Senses, 2001 Sep. PMID 11555487, Free PMC Article
  4. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There exists an Ub-independent alternative pathway that promotesAurora-A degradation and AURKAIP1 promotes Aurora-A degradation through this Ub-independent yet proteasome-dependent pathway.
    Title: Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within positive regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS38
Names
28S ribosomal protein S38, mitochondrial
AURKA-interacting protein
Aurora-A kinase interacting protein
aurora kinase A-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025338.4 → NP_079614.1  small ribosomal subunit protein mS38

    See identical proteins and their annotated locations for NP_079614.1

    Status: VALIDATED

    Source sequence(s)
    AK003442, AL670236, CX233396
    Consensus CDS
    CCDS19043.1
    UniProtKB/Swiss-Prot
    Q9D1J7, Q9DCJ7
    UniProtKB/TrEMBL
    Q3TZ21, Q8CCC0
    Related
    ENSMUSP00000081114.6, ENSMUST00000084097.12
    Conserved Domains (1) summary
    pfam08213
    Location:128 → 160
    DUF1713; Mitochondrial domain of unknown function (DUF1713)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155915709..155917555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539095.4 → XP_006539158.1  small ribosomal subunit protein mS38 isoform X1

    See identical proteins and their annotated locations for XP_006539158.1

    UniProtKB/Swiss-Prot
    Q9D1J7, Q9DCJ7
    UniProtKB/TrEMBL
    Q3TZ21, Q8CCC0
    Related
    ENSMUSP00000101216.2, ENSMUST00000105591.2
    Conserved Domains (1) summary
    pfam08213
    Location:128 → 160
    DUF1713; Mitochondrial domain of unknown function (DUF1713)

  2. XM_036164304.1 → XP_036020197.1  small ribosomal subunit protein mS38 isoform X1

    UniProtKB/Swiss-Prot
    Q9D1J7, Q9DCJ7
    UniProtKB/TrEMBL
    Q3TZ21, Q8CCC0
    Related
    ENSMUSP00000101217.2, ENSMUST00000105592.8
    Conserved Domains (1) summary
    pfam08213
    Location:128 → 160
    DUF1713; Mitochondrial domain of unknown function (DUF1713)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCJ7.2 GenPept UniProtKB/Swiss-Prot:Q9DCJ7

Gene LinkOut

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