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Gtpbp8 GTP-binding protein 8 (putative) [ Mus musculus (house mouse) ]

Gene ID: 66067, updated on 5-Mar-2024

Summary

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Official Symbol
Gtpbp8provided by MGI
Official Full Name
GTP-binding protein 8 (putative)provided by MGI
Primary source
MGI:MGI:1913317
See related
Ensembl:ENSMUSG00000022668 AllianceGenome:MGI:1913317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610037H22Rik
Summary
Predicted to enable GTP binding activity and metal ion binding activity. Located in mitochondrion. Orthologous to human GTPBP8 (GTP binding protein 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 6.8), CNS E18 (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gtpbp8 in Genome Data Viewer
Location:
16 B4; 16 29.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (44559242..44566726, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (44738879..44746363, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30311 Neighboring gene VISTA enhancer mm1637 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:44692039-44692222 Neighboring gene STARR-seq mESC enhancer starr_40911 Neighboring gene STARR-positive B cell enhancer ABC_E10905 Neighboring gene predicted gene, 30445 Neighboring gene nucleolus and neural progenitor protein Neighboring gene STARR-positive B cell enhancer mm9_chr16:44746411-44746712 Neighboring gene STARR-positive B cell enhancer ABC_E5543 Neighboring gene CD200 receptor 1 Neighboring gene lactate dehydrogenase A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptomic analysis of the upper lip and primary palate development in mice. Cai S, et al. Front Genet, 2022. PMID 36685938, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130125, MGC130126

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159329.1 → NP_001152801.1  GTP-binding protein 8 isoform 2

    See identical proteins and their annotated locations for NP_001152801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC107217, BE197762, CJ169587
    Consensus CDS
    CCDS49855.1
    UniProtKB/Swiss-Prot
    Q9CY28
    Related
    ENSMUSP00000023348.5, ENSMUST00000023348.11
    Conserved Domains (2) summary
    cd01876
    Location:47 → 214
    YihA_EngB; YihA (EngB) GTPase family
    TIGR00231
    Location:46 → 203
    small_GTP; small GTP-binding protein domain

  2. NM_001356392.1 → NP_001343321.1  GTP-binding protein 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122217
    UniProtKB/TrEMBL
    F6XXP5
    Related
    ENSMUSP00000123974.2, ENSMUST00000161436.2
    Conserved Domains (1) summary
    cd01876
    Location:114 → 248
    YihA_EngB; YihA (EngB) GTPase family

  3. NM_025332.3 → NP_079608.1  GTP-binding protein 8 isoform 1

    See identical proteins and their annotated locations for NP_079608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK147840, BE197762, CJ169587
    Consensus CDS
    CCDS28188.1
    UniProtKB/Swiss-Prot
    Q3KNM0, Q9CY28
    UniProtKB/TrEMBL
    F6XXP5
    Related
    ENSMUSP00000125352.2, ENSMUST00000162512.8
    Conserved Domains (2) summary
    cd01876
    Location:113 → 281
    YihA_EngB; YihA (EngB) GTPase family
    pfam00009
    Location:114 → 273
    GTP_EFTU; Elongation factor Tu GTP binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    44559242..44566726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY28.1 GenPept UniProtKB/Swiss-Prot:Q9CY28

Gene LinkOut

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