Sf3b6 splicing factor 3B, subunit 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sf3b6provided by MGI
Official Full Name: splicing factor 3B, subunit 6provided by MGI
Primary source: MGI:MGI:1913305
See related: Ensembl:ENSMUSG00000037361 AllianceGenome:MGI:1913305
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sf3b14; 0610009D07Rik; 6030419K15Rik
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within blastocyst formation and mRNA splicing, via spliceosome. Located in nucleus. Is expressed in central nervous system; early conceptus; secondary oocyte; and sensory organ. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 55.9), bladder adult (RPKM 52.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 2.09 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (4867608..4877659)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (4817608..4827659)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sf3b14 is required for the blastocyst formation.
Title: Identification of four genes required for mammalian blastocyst formation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV001342 (e-PCR)
- UniSTS:165597

0610009D07Rik (e-PCR), detects polymorphism
- UniSTS:478970

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of U12-type spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U12-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of U2 snRNP	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of precatalytic spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of spliceosomal complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: splicing factor 3B subunit 6

Names: SF3B 14 kDa subunit; pre-mRNA branch site protein p14; splicing factor 3B, 14 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025323.2 → NP_079599.1 splicing factor 3B subunit 6

See identical proteins and their annotated locations for NP_079599.1

Status: PROVISIONAL

Source sequence(s)

BC019535

Consensus CDS

CCDS25791.1

UniProtKB/Swiss-Prot

P59708, Q3U9T9

UniProtKB/TrEMBL

A0A1W2P7L7

Related

ENSMUSP00000043662.8, ENSMUST00000046207.9

Conserved Domains (1) summary

cd12241
Location:17 → 93

RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins