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Cndp2 CNDP dipeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 66054, updated on 5-Mar-2024

Summary

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Official Symbol
Cndp2provided by MGI
Official Full Name
CNDP dipeptidase 2provided by MGI
Primary source
MGI:MGI:1913304
See related
Ensembl:ENSMUSG00000024644 AllianceGenome:MGI:1913304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cn2; Pep1; Dip-2; Pep-1; 0610010E05Rik
Summary
Enables dipeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including 1st branchial arch; ear; limb; nervous system; and urinary system. Orthologous to human CNDP2 (carnosine dipeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 201.3), placenta adult (RPKM 117.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Cndp2 in Genome Data Viewer
Location:
18 E4; 18 57.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84685590..84703827, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84667465..84685702, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene carnosine dipeptidase 1 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene STARR-seq mESC enhancer starr_45252 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene STARR-seq mESC enhancer starr_45255 Neighboring gene WD repeat domain 53 pseudogene Neighboring gene divergent protein kinase domain 1C Neighboring gene predicted gene, 25005

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides. Kobayashi S, et al. Free Radic Biol Med, 2021 Oct. PMID 34324979
  2. Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics. Kim JT, et al. Cell Chem Biol, 2019 Nov 21. PMID 31587987, Free PMC Article
  3. Evidence for an essential role of intradimer interaction in catalytic function of carnosine dipeptidase II using electrospray-ionization mass spectrometry. Okumura N, et al. Protein Sci, 2016 Feb. PMID 26549037, Free PMC Article
  4. Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2. Unno H, et al. J Biol Chem, 2008 Oct 3. PMID 18550540
  5. An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, et al. Nature, 2022 Jun. PMID 35705806, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models
    Title: PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models.
  2. These results provide evidence showing that intradimer interaction of H228 with the reaction center of the dimer counterpart is essential to the enzymatic activity of Cn2.
    Title: Evidence for an essential role of intradimer interaction in catalytic function of carnosine dipeptidase II using electrospray-ionization mass spectrometry.
  3. These findings suggest that the transduced PEP-1-PRX2 has neuroprotective functions against oxidative stress-induced cell death in vitro and in vivo
    Title: Neuroprotective effect of PEP-1-peroxiredoxin2 on CA1 regions in the hippocampus against ischemic insult.
  4. Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
    Title: Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alanylglutamate dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic non-specific dipeptidase
Names
CNDP dipeptidase 2 (metallopeptidase M20 family)
cytosolic nonspecific dipeptidase
glutamate carboxypeptidase-like protein 1
peptidase 1
peptidase A
threonyl dipeptidase
NP_001276460.1
NP_075638.2
XP_030106430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289531.1 → NP_001276460.1  cytosolic non-specific dipeptidase

    See identical proteins and their annotated locations for NP_001276460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein
    Source sequence(s)
    AK003779, AK152442, CJ306472, CN721222
    Consensus CDS
    CCDS29383.1
    UniProtKB/Swiss-Prot
    Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
    UniProtKB/TrEMBL
    Q6KAT3
    Related
    ENSMUSP00000128696.2, ENSMUST00000168419.3
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

  2. NM_023149.3 → NP_075638.2  cytosolic non-specific dipeptidase

    See identical proteins and their annotated locations for NP_075638.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003779, CJ078789, CJ306472
    Consensus CDS
    CCDS29383.1
    UniProtKB/Swiss-Prot
    Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
    UniProtKB/TrEMBL
    Q6KAT3
    Related
    ENSMUSP00000025546.10, ENSMUST00000025546.17
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84685590..84703827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250570.2 → XP_030106430.1  cytosolic non-specific dipeptidase isoform X1

    UniProtKB/Swiss-Prot
    Q3TA80, Q3TI32, Q3U7B9, Q99PV1, Q9D1A2
    UniProtKB/TrEMBL
    Q6KAT3
    Conserved Domains (1) summary
    cd05676
    Location:7 → 473
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1A2.1 GenPept UniProtKB/Swiss-Prot:Q9D1A2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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