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Atp5f1d ATP synthase F1 subunit delta [ Mus musculus (house mouse) ]

Gene ID: 66043, updated on 11-Apr-2024

Summary

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Official Symbol
Atp5f1dprovided by MGI
Official Full Name
ATP synthase F1 subunit deltaprovided by MGI
Primary source
MGI:MGI:1913293
See related
Ensembl:ENSMUSG00000003072 AllianceGenome:MGI:1913293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5d; 0610008F14Rik; 1500000I11Rik
Summary
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport and mitochondrial proton-transporting ATP synthase complex assembly. Predicted to act upstream of or within proton transmembrane transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 1424.1), adrenal adult (RPKM 1222.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79974451..79981662)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80138698..80145828)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene strawberry notch 2 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79621397-79621506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79622453-79622640 Neighboring gene midnolin Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene cold inducible RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATP5D Is a Potential Biomarker for Male Fertility. Wang YB, et al. Oxid Med Cell Longev, 2023. PMID 36686378, Free PMC Article
  2. Role of the mitochondrial ATP synthase central stalk subunits γ and δ in the activity and assembly of the mammalian enzyme. Pecina P, et al. Biochim Biophys Acta Bioenerg, 2018 May. PMID 29499186
  3. Identification of a new Mpl-interacting protein, Atp5d. Liu H, et al. Mol Cell Biochem, 2014 Jun. PMID 24615392
  4. Copy number variation modifies expression time courses. Chaignat E, et al. Genome Res, 2011 Jan. PMID 21084671, Free PMC Article
  5. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP5D Is a Potential Biomarker for Male Fertility.
    Title: ATP5D Is a Potential Biomarker for Male Fertility.
  2. Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation.
    Title: Role of the mitochondrial ATP synthase central stalk subunits γ and δ in the activity and assembly of the mammalian enzyme.
  3. The interaction between Mpl and Atp5d was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro.
    Title: Identification of a new Mpl-interacting protein, Atp5d.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial envelope ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
part_of proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex, catalytic core F(1) ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP synthase subunit delta, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
F-ATPase delta subunit
NP_001334021.1
NP_079589.2
XP_017169541.1
XP_030101070.1
XP_030101071.1
XP_030101072.1
XP_030101073.1
XP_036011835.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347092.1 → NP_001334021.1  ATP synthase subunit delta, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BE951291, BM948933, CX200198
    Consensus CDS
    CCDS83726.1
    UniProtKB/TrEMBL
    D3Z7S4
    Related
    ENSMUSP00000101005.2, ENSMUST00000105366.2
    Conserved Domains (1) summary
    cd12152
    Location:38 → 98
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

  2. NM_025313.2 → NP_079589.2  ATP synthase subunit delta, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_079589.2

    Status: VALIDATED

    Source sequence(s)
    AA409366, AK151151, BY451544
    Consensus CDS
    CCDS24010.1
    UniProtKB/Swiss-Prot
    Q9D3D9
    UniProtKB/TrEMBL
    Q4FK74, Q9D0J2, Q9DCZ0
    Related
    ENSMUSP00000003156.9, ENSMUST00000003156.15
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79974451..79981662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314052.3 → XP_017169541.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D9
    UniProtKB/TrEMBL
    Q4FK74, Q9D0J2, Q9DCZ0
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

  2. XM_030245212.2 → XP_030101072.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D9
    UniProtKB/TrEMBL
    Q4FK74, Q9D0J2, Q9DCZ0
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

  3. XM_030245213.2 → XP_030101073.1  ATP synthase subunit delta, mitochondrial isoform X2

    UniProtKB/TrEMBL
    D3Z7S4
    Conserved Domains (1) summary
    cd12152
    Location:38 → 98
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

  4. XM_036155942.1 → XP_036011835.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D9
    UniProtKB/TrEMBL
    Q4FK74, Q9D0J2, Q9DCZ0
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

  5. XM_030245211.2 → XP_030101071.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D9
    UniProtKB/TrEMBL
    Q4FK74, Q9D0J2, Q9DCZ0
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit

  6. XM_030245210.2 → XP_030101070.1  ATP synthase subunit delta, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9D3D9
    UniProtKB/TrEMBL
    Q4FK74, Q9D0J2, Q9DCZ0
    Related
    ENSMUSP00000101006.2, ENSMUST00000105367.8
    Conserved Domains (1) summary
    cd12152
    Location:38 → 162
    F1-ATPase_delta; mitochondrial ATP synthase delta subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3D9.1 GenPept UniProtKB/Swiss-Prot:Q9D3D9

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