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ZBTB10 zinc finger and BTB domain containing 10 [ Homo sapiens (human) ]

Gene ID: 65986, updated on 5-Mar-2024

Summary

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Official Symbol
ZBTB10provided by HGNC
Official Full Name
zinc finger and BTB domain containing 10provided by HGNC
Primary source
HGNC:HGNC:30953
See related
Ensembl:ENSG00000205189 MIM:618576; AllianceGenome:HGNC:30953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RINZF
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 6.2), placenta (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q21.13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (80485593..80526265)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (80917153..80957852)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (81397828..81438500)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375922 Neighboring gene uncharacterized LOC105375921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:81398027-81398597 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:81398598-81399168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:81415452-81415952 Neighboring gene long intergenic non-protein coding RNA 2986 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:81470238-81471437 Neighboring gene ribosomal protein SA pseudogene 47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural insights into the recognition of telomeric variant repeat TTGGGG by broad-complex, tramtrack and bric-à-brac - zinc finger protein ZBTB10. Wang S, et al. J Biol Chem, 2023 Mar. PMID 36657642, Free PMC Article
  2. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Pathi SS, et al. Mol Cancer Res, 2011 Feb. PMID 21156786, Free PMC Article
  3. MiR-361-5p promotes proliferation and inhibits apoptosis of fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid arthritis. Zhang A, et al. Autoimmunity, 2022 Aug. PMID 35608340
  4. Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency. Wen YC, et al. Cell Death Dis, 2022 Mar 19. PMID 35306527, Free PMC Article
  5. The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Noratto GD, et al. Mol Nutr Food Res, 2013 Sep. PMID 23471840

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.
    Title: Intermittent Hypoxia Promotes TAM-Induced Glycolysis in Laryngeal Cancer Cells via Regulation of HK1 Expression through Activation of ZBTB10.
  2. Structural insights into the recognition of telomeric variant repeat TTGGGG by broad-complex, tramtrack and bric-a-brac - zinc finger protein ZBTB10.
    Title: Structural insights into the recognition of telomeric variant repeat TTGGGG by broad-complex, tramtrack and bric-à-brac - zinc finger protein ZBTB10.
  3. MiR-361-5p promotes proliferation and inhibits apoptosis of fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid arthritis.
    Title: MiR-361-5p promotes proliferation and inhibits apoptosis of fibroblast-like synoviocytes via targeting ZBTB10 in rheumatoid arthritis.
  4. Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency.
    Title: Pyruvate kinase L/R links metabolism dysfunction to neuroendocrine differentiation of prostate cancer by ZBTB10 deficiency.
  5. ZBTB10 co-localizes with a subset of telomeres in ALT-positive U2OS cells and interacts with TRF2/RAP1 via the N-terminal region of TRF2. Our data establishes ZBTB10 as a novel variant repeat binding protein at ALT telomeres.
    Title: ZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2.
  6. Sp1, Sp3, and Sp4 and Sp-regulated genes were downregulated by curcuminoids in SW-480 and this was accompanied by suppression of microRNA-27a (miR-27a) and induction of ZBTB10, an mRNA target of miR-27a and a transcriptional repressor of Sp expression.
    Title: The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.
  7. Collectively, these results indicated that stimulation of ovarian cancer cell VEGF, Cox2 and survivin expression by FSH involves the microRNA27a: ZBTB10-specificity protein pathway.
    Title: The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells.
  8. Study show that miR-27a indirectly regulates E2-responsiveness in MCF-7 cells through suppression of ZBTB10, thereby enhancing expression of ERalpha.
    Title: MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
EBI GWAS Catalog
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
EBI GWAS Catalog
Novel associations for hypothyroidism include known autoimmune risk loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12752

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 10
Names
zinc finger protein RIN ZF
zinc finger protein RINZF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105539.3 → NP_001099009.1  zinc finger and BTB domain-containing protein 10 isoform a

    See identical proteins and their annotated locations for NP_001099009.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC009812, AI627858, BC050061, BC127098
    Consensus CDS
    CCDS47880.1
    UniProtKB/Swiss-Prot
    A4FVD0, Q86W96, Q8IXI9, Q96DT7, Q96MH9
    UniProtKB/TrEMBL
    A8E4L4
    Related
    ENSP00000412036.3, ENST00000455036.8
    Conserved Domains (5) summary
    smart00597
    Location:249 → 316
    ZnF_TTF; zinc finger in transposases and transcription factors
    sd00017
    Location:724 → 744
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18201
    Location:343 → 464
    BTB_POZ_ZBTB10; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10)
    pfam13465
    Location:737 → 761
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:722 → 746
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. NM_001277145.2 → NP_001264074.1  zinc finger and BTB domain-containing protein 10 isoform c

    See identical proteins and their annotated locations for NP_001264074.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC009812, AI627858, AK056913
    Consensus CDS
    CCDS64920.1
    UniProtKB/Swiss-Prot
    Q96DT7
    Related
    ENSP00000368384.4, ENST00000379091.8
    Conserved Domains (4) summary
    sd00017
    Location:432 → 452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:51 → 172
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam13465
    Location:445 → 469
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:430 → 454
    zf-H2C2_5; C2H2-type zinc-finger domain

  3. NM_023929.5 → NP_076418.3  zinc finger and BTB domain-containing protein 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in an internal exon, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC009812, AI627858, AK022814, BC127098
    UniProtKB/Swiss-Prot
    Q96DT7
    UniProtKB/TrEMBL
    Q9H9H3
    Related
    ENSP00000416134.2, ENST00000426744.5
    Conserved Domains (6) summary
    smart00225
    Location:365 → 461
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00597
    Location:249 → 316
    ZnF_TTF; zinc finger in transposases and transcription factors
    sd00017
    Location:700 → 720
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:354 → 460
    BTB; BTB/POZ domain
    pfam13465
    Location:713 → 737
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:698 → 720
    zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    80485593..80526265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    80917153..80957852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DT7.2 GenPept UniProtKB/Swiss-Prot:Q96DT7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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