GSTT2B glutathione S-transferase theta 2B [Homo sapiens (human)] - Gene

Summary

Official Symbol: GSTT2Bprovided by HGNC
Official Full Name: glutathione S-transferase theta 2Bprovided by HGNC
Primary source: HGNC:HGNC:33437
See related: Ensembl:ENSG00000133433 AllianceGenome:HGNC:33437
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GSTT2P
Summary: The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Annotation information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression: Broad expression in adrenal (RPKM 23.9), skin (RPKM 19.2) and 21 other tissues See more
Orthologs: all
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Genomic context

Location:: 22q11.23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (23957414..23961206, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (24299601..24303393, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data highlights that GSTT2B copy number variant is not associated with the investigated complex diseases in Italian patients.
Title: Explorative genetic association study of GSTT2B copy number variant in complex disease risks.
Results GSTT2B insertion allele was associated with an increased risk of being small for gestational age indicate that
Title: Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes.
results suggest that the presence of the recently described GSTT2B deletion may have a protective effect on the risk of OSCC in the Mixed Ancestry South African population
Title: Association of a deletion of GSTT2B with an altered risk of oesophageal squamous cell carcinoma in a South African population: a case-control study.
study describes a previously uncharacterized 38-kilo-base (kb) long deletion polymorphism of GSTT2B located within a 61-kb DNA inverted repeat
Title: Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R08187 (e-PCR)
- UniSTS:16247

D22S1106 (e-PCR)
- UniSTS:52936

GSTT2_2655 (e-PCR)
- UniSTS:463597

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase theta-2B

Names: GST class-theta-2; glutathione S-transferase theta 2

NP_001074312.1

EC 2.5.1.18

NP_001350733.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080843.4 → NP_001074312.1 glutathione S-transferase theta-2B isoform 1

See identical proteins and their annotated locations for NP_001074312.1

Status: VALIDATED

Source sequence(s)

AC253536

Consensus CDS

CCDS33617.1

UniProtKB/Swiss-Prot

P0CG30

UniProtKB/TrEMBL

B2R533, G9J6Q4, G9J6Q5, G9J6Q6

Related

ENSP00000290765.4, ENST00000290765.9

Conserved Domains (2) summary

cd03183
Location:91 → 216

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
NM_001363804.1 → NP_001350733.1 glutathione S-transferase theta-2B isoform 2

Status: VALIDATED

Source sequence(s)

AC253536

Consensus CDS

CCDS87010.1

UniProtKB/TrEMBL

B2R533, G9J6Q4, G9J6Q6, Q6IB75, Q6ICJ4

Related

ENSP00000385116.3, ENST00000404172.3

Conserved Domains (2) summary

cd03183
Location:91 → 202

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...