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TMEM183BP transmembrane protein 183B, pseudogene [ Homo sapiens (human) ]

Gene ID: 653659, updated on 23-Nov-2023

Summary

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Official Symbol
TMEM183BPprovided by HGNC
Official Full Name
transmembrane protein 183B, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:33205
See related
Ensembl:ENSG00000224831 MIM:611365; AllianceGenome:HGNC:33205
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM183B; C1ORF37DUP; C1orf37-DUP
Summary
This locus was thought to represent a pseudogene of chromosome 1 open reading frame 37 because it is intronless and retains a polyA tail at the 3' end. It does however contain a complete open reading frame that subsequent research has demonstrated to be transcribed in a limited number of human tissues. The encoded protein may represent a transmembrane protein associated with cell membranes and be involved in cell-cell or cell-environment interactions. [provided by RefSeq, Jul 2010]
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Genomic context

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Location:
3q25.1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (149982269..149983308, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (152733645..152734684, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149700056..149701095, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene profilin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14811 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14812 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:149688883-149689414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:149689415-149689945 Neighboring gene uncharacterized LOC646903 Neighboring gene peptidylprolyl isomerase A pseudogene 73 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:149710371-149710872 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup. Yu H, et al. Hum Mol Genet, 2006 Jun 1. PMID 16644869
  2. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • transmembrane protein 183B

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_070995.1 

    Range
    101..1140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    149982269..149983308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    152733645..152734684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001079809.2: Suppressed sequence

    Description
    NM_001079809.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1AE95.1 GenPept UniProtKB/Swiss-Prot:Q1AE95

Gene LinkOut

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