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Mymx myomixer, myoblast fusion factor [ Mus musculus (house mouse) ]

Gene ID: 653016, updated on 21-Apr-2024

Summary

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Official Symbol
Mymxprovided by MGI
Official Full Name
myomixer, myoblast fusion factorprovided by MGI
Primary source
MGI:MGI:3649059
See related
Ensembl:ENSMUSG00000079471 AllianceGenome:MGI:3649059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Esgp; Gm7325; minion; EG653016; myomerger
Summary
Involved in myoblast fusion involved in skeletal muscle regeneration; plasma membrane fusion; and skeletal muscle organ development. Located in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is integral component of plasma membrane. Is expressed in diaphragm; foregut; limb; skeletal musculature; and tail paraxial mesenchyme. Orthologous to human MYMX (myomixer, myoblast fusion factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 9.7), kidney adult (RPKM 1.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 C; 17 22.59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45911887..45913122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45600961..45602196, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45710735-45710975 Neighboring gene STARR-positive B cell enhancer ABC_E10955 Neighboring gene predicted gene, 35399 Neighboring gene STARR-positive B cell enhancer ABC_E8678 Neighboring gene solute carrier family 29 (nucleoside transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_42635 Neighboring gene STARR-seq mESC enhancer starr_42636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45756550-45756733 Neighboring gene predicted gene, 52283 Neighboring gene predicted gene, 25008 Neighboring gene STARR-positive B cell enhancer ABC_E9955 Neighboring gene STARR-positive B cell enhancer ABC_E10956 Neighboring gene calpain 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45775877-45776144

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm. Golani G, et al. Nat Commun, 2021 Jan 21. PMID 33479215, Free PMC Article
  2. Molecular cloning and functional analysis of ESGP, an embryonic stem cell and germ cell specific protein. Chen YM, et al. Acta Biochim Biophys Sin (Shanghai), 2005 Dec. PMID 16331322
  3. Gm7325 is MyoD-dependently expressed in activated muscle satellite cells. Takei D, et al. Biomed Res, 2017. PMID 28637957
  4. Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration. Bi P, et al. Proc Natl Acad Sci U S A, 2018 Apr 10. PMID 29581287, Free PMC Article
  5. IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger. Kurosaka M, et al. Cells, 2023 Apr 29. PMID 37174683, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
    Title: IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
  2. Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm.
    Title: Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm.
  3. myomerger is a fundamental myoblast fusion protein with roles in skeletal muscle development
    Title: Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development.
  4. Minion is a novel microprotein required for muscle development
    Title: The microprotein Minion controls cell fusion and muscle formation.
  5. Genetic deletion of Myomixer in satellite cells abolishes satellite cell fusion and prevents muscle regeneration, resulting in severe muscle degeneration after injury.
    Title: Fusogenic micropeptide Myomixer is essential for satellite cell fusion and muscle regeneration.
  6. Gm7325, as a novel MyoD-target gene, is specifically induced in activated satellite cells, and may have an important role in skeletal myogenesis.
    Title: Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.
  7. the Myomixer-Myomaker pair controls the critical step in myofiber formation during muscle development.
    Title: Control of muscle formation by the fusogenic micropeptide myomixer.
  8. The expression of ESGP is consistent with the expression of Oct-4 during embryonic development.Forced expression of ESGP is not indispensable for the effect of Oct-4 on ES cell self-renewal, and does not affect the differentiation to three germ layers.
    Title: Molecular cloning and functional analysis of ESGP, an embryonic stem cell and germ cell specific protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myoblast fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in myoblast fusion involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal muscle organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein myomixer
Names
embryonic stem cell- and germ cell-specific protein
microprotein inducer of fusion
protein minion
protein myomerger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177468.1 → NP_001170939.1  protein myomixer isoform 1

    See identical proteins and their annotated locations for NP_001170939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BB399187, CJ191178, W70601
    Consensus CDS
    CCDS50119.1
    UniProtKB/Swiss-Prot
    E9PXI1, Q2Q5T5
    UniProtKB/TrEMBL
    A0A223PZC0
    Related
    ENSMUSP00000137630.2, ENSMUST00000178858.3
    Conserved Domains (1) summary
    cd20278
    Location:20 → 64
    Minion; Microprotein INducer of fusION (Minion)

  2. NM_001177469.1 → NP_001170940.1  protein myomixer isoform 1

    See identical proteins and their annotated locations for NP_001170940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC163677, BB399187, CJ191178, W70601
    Consensus CDS
    CCDS50119.1
    UniProtKB/Swiss-Prot
    E9PXI1, Q2Q5T5
    UniProtKB/TrEMBL
    A0A223PZC0
    Related
    ENSMUSP00000109157.3, ENSMUST00000113529.4
    Conserved Domains (1) summary
    cd20278
    Location:20 → 64
    Minion; Microprotein INducer of fusION (Minion)

  3. NM_001177470.1 → NP_001170941.1  protein myomixer isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1, resulting in translation initiation from an in-frame upstream AUG and a longer isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BB399187, CJ043848, CJ062905, CJ191178
    Consensus CDS
    CCDS50120.1
    UniProtKB/Swiss-Prot
    Q2Q5T5
    Related
    ENSMUSP00000126690.2, ENSMUST00000169137.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45911887..45913122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524789.3 → XP_006524852.1  protein myomixer isoform X1

    See identical proteins and their annotated locations for XP_006524852.1

    UniProtKB/Swiss-Prot
    E9PXI1, Q2Q5T5
    UniProtKB/TrEMBL
    A0A223PZC0
    Conserved Domains (1) summary
    cd20278
    Location:20 → 64
    Minion; Microprotein INducer of fusION (Minion)

  2. XM_006524790.1 → XP_006524853.1  protein myomixer isoform X1

    See identical proteins and their annotated locations for XP_006524853.1

    UniProtKB/Swiss-Prot
    E9PXI1, Q2Q5T5
    UniProtKB/TrEMBL
    A0A223PZC0
    Related
    ENSMUSP00000146823.2, ENSMUST00000208801.2
    Conserved Domains (1) summary
    cd20278
    Location:20 → 64
    Minion; Microprotein INducer of fusION (Minion)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2Q5T5.1 GenPept UniProtKB/Swiss-Prot:Q2Q5T5

Gene LinkOut

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