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Xpo7 exportin 7 [ Mus musculus (house mouse) ]

Gene ID: 65246, updated on 5-Mar-2024

Summary

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Official Symbol
Xpo7provided by MGI
Official Full Name
exportin 7provided by MGI
Primary source
MGI:MGI:1929705
See related
Ensembl:ENSMUSG00000022100 AllianceGenome:MGI:1929705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
exp7; Ranbp16; 4930506C02Rik
Summary
Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. Is expressed in heart and liver. Orthologous to human XPO7 (exportin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 28.1), liver E14 (RPKM 26.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D2; 14 36.44 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70899566..71004075, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70662126..70770864, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37085 Neighboring gene predicted gene, 38605 Neighboring gene fibroblast growth factor 17 Neighboring gene predicted gene, 52133 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene STARR-seq mESC enhancer starr_37090 Neighboring gene PCNA-associated factor pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7334 Neighboring gene STARR-seq mESC enhancer starr_37093 Neighboring gene docking protein 2 Neighboring gene predicted gene, 34442 Neighboring gene predicted gene, 34500

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus. Markiewicz Ł, et al. Cell Signal, 2021 Apr. PMID 33383157
  2. Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation. Hattangadi SM, et al. Blood, 2014 Sep 18. PMID 25092175, Free PMC Article
  3. The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation. Cantú I, et al. PLoS One, 2019. PMID 30921348, Free PMC Article
  4. miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression. Figueroa AA, et al. Haematologica, 2018 Aug. PMID 29567782, Free PMC Article
  5. Astrocytic exportin-7 responds to ischemia through mediating LKB1 translocation from the nucleus to the cytoplasm. Liang HJ, et al. J Neurosci Res, 2015 Feb. PMID 25250856

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
    Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
  2. An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.
    Title: An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.
  3. Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
    Title: Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
  4. Results found that XPO7 expression was significantly downregulated in the presence of the KLF1 Nan variant erythroid progenitors, potentially contributing to increased nuclear size.
    Title: The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.
  5. miR-181a is down-regulated during erythroid development and its expression inversely correlated with Xpo7 induction.
    Title: miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression.
  6. Knockdown of Xpo7 in primary fetal liver erythroblasts resulted in severe inhibition of chromatin condensation and enucleation but otherwise had little effect on erythroid differentiation, including hemoglobin accumulation.
    Title: Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation.
  7. This study demonstrateg that exportin-7 responds to ischemia in astrocytes.
    Title: Astrocytic exportin-7 responds to ischemia through mediating LKB1 translocation from the nucleus to the cytoplasm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA0745

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exportin-7
Names
RAN binding protein 16
ran-binding protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359888.1 → NP_001346817.1  exportin-7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA051428, AI431041, AK036837, AK039776, AK143729
    Consensus CDS
    CCDS88710.1
    UniProtKB/TrEMBL
    A0A2I3BQV5, E9PUW7
    Related
    ENSMUSP00000154350.2, ENSMUST00000228346.2
    Conserved Domains (2) summary
    smart00913
    Location:31 → 97
    IBN_N; Importin-beta N-terminal domain
    COG5101
    Location:30 → 306
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  2. NM_023045.3 → NP_075532.1  exportin-7 isoform 2

    See identical proteins and their annotated locations for NP_075532.1

    Status: VALIDATED

    Source sequence(s)
    AA051428, AC125180, AI431041, AK036837, AK039776, AK164595, CA325231
    Consensus CDS
    CCDS36974.1
    UniProtKB/Swiss-Prot
    Q3TP94, Q80TS9, Q8BSK5, Q8C9M7, Q8CB42, Q8CBL8, Q8CEF5, Q9EPK7
    UniProtKB/TrEMBL
    E9PUW7
    Related
    ENSMUSP00000022696.7, ENSMUST00000022696.8
    Conserved Domains (2) summary
    smart00913
    Location:30 → 96
    IBN_N; Importin-beta N-terminal domain
    COG5101
    Location:29 → 305
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70899566..71004075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247914.2 → XP_030103774.1  exportin-7 isoform X2

    UniProtKB/TrEMBL
    E9PUW7
    Related
    ENSMUSP00000153855.2, ENSMUST00000226448.2
    Conserved Domains (2) summary
    smart00913
    Location:30 → 96
    IBN_N; Importin-beta N-terminal domain
    COG5101
    Location:29 → 314
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  2. XM_006519359.4 → XP_006519422.1  exportin-7 isoform X1

    UniProtKB/TrEMBL
    E9PUW7
    Conserved Domains (2) summary
    smart00913
    Location:31 → 97
    IBN_N; Importin-beta N-terminal domain
    COG5101
    Location:30 → 315
    CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

  3. XM_011245132.4 → XP_011243434.1  exportin-7 isoform X3

    UniProtKB/TrEMBL
    E9PUW7
    Conserved Domains (1) summary
    pfam03810
    Location:4 → 48
    IBN_N; Importin-beta N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPK7.3 GenPept UniProtKB/Swiss-Prot:Q9EPK7

Gene LinkOut

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