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ZFP69B ZFP69 zinc finger protein B [ Homo sapiens (human) ]

Gene ID: 65243, updated on 5-Mar-2024

Summary

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Official Symbol
ZFP69Bprovided by HGNC
Official Full Name
ZFP69 zinc finger protein Bprovided by HGNC
Primary source
HGNC:HGNC:28053
See related
Ensembl:ENSG00000187801 AllianceGenome:HGNC:28053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF643; ZSCAN54B; ZKSCAN23B
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 1.6), appendix (RPKM 1.1) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40450064..40463715)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40319624..40333275)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40915736..40929387)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 844 Neighboring gene small ArfGAP2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:40839657-40840156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 845 Neighboring gene Sharpr-MPRA regulatory region 11139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 728 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:40916242-40917441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 729 Neighboring gene ZFP69 zinc finger protein Neighboring gene EXO5 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 847 Neighboring gene exonuclease 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. Serebrenik YV, et al. Mol Biol Cell, 2018 Jun 1. PMID 29851555, Free PMC Article
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. TRABID targets DDB2 for deubiquitination to promote proliferation of hepatocellular carcinoma cells. Chen Y, et al. Biochem Biophys Res Commun, 2022 Oct 15. PMID 35944360

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF643/ZFP69B Exerts Oncogenic Properties and Associates with Cell Adhesion and Immune Processes.
    Title: ZNF643/ZFP69B Exerts Oncogenic Properties and Associates with Cell Adhesion and Immune Processes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ34293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 69 homolog B
Names
novel zinc finger protein
zinc finger protein 643
zinc finger protein ZFP69B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369565.1 → NP_001356494.1  zinc finger protein 69 homolog B

    Status: VALIDATED

    Source sequence(s)
    AL031985
    Consensus CDS
    CCDS452.2
    UniProtKB/Swiss-Prot
    Q5QPL4, Q9UJL9
    Related
    ENSP00000399664.2, ENST00000411995.6
    Conserved Domains (5) summary
    smart00349
    Location:74 → 133
    KRAB; krueppel associated box
    COG5048
    Location:221 → 429
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:309 → 329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:433 → 458
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:2 → 40
    SCAN; SCAN oligomerization domain

  2. NM_023070.3 → NP_075558.2  zinc finger protein 69 homolog B

    See identical proteins and their annotated locations for NP_075558.2

    Status: VALIDATED

    Source sequence(s)
    AL031985, BC017498, CN256362
    Consensus CDS
    CCDS452.2
    UniProtKB/Swiss-Prot
    Q5QPL4, Q9UJL9
    Related
    ENSP00000354547.4, ENST00000361584.5
    Conserved Domains (5) summary
    smart00349
    Location:74 → 133
    KRAB; krueppel associated box
    COG5048
    Location:221 → 429
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:309 → 329
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:433 → 458
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:2 → 40
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40450064..40463715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271136.2 → XP_005271193.1  zinc finger protein 69 homolog B isoform X1

    Related
    ENST00000469416.1
    Conserved Domains (5) summary
    smart00349
    Location:74 → 134
    KRAB; krueppel associated box
    COG5048
    Location:194 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:434 → 459
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:2 → 40
    SCAN; SCAN oligomerization domain

  2. XM_017002147.2 → XP_016857636.1  zinc finger protein 69 homolog B isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:74 → 134
    KRAB; krueppel associated box
    COG5048
    Location:194 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:310 → 330
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:434 → 459
    zf-H2C2_2; Zinc-finger double domain
    cl02605
    Location:2 → 40
    SCAN; SCAN oligomerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40319624..40333275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338413.1 → XP_054194388.1  zinc finger protein 69 homolog B isoform X1

  2. XM_054338414.1 → XP_054194389.1  zinc finger protein 69 homolog B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJL9.2 GenPept UniProtKB/Swiss-Prot:Q9UJL9

Gene LinkOut

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