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Bean1 brain expressed, associated with Nedd4, 1 [ Mus musculus (house mouse) ]

Gene ID: 65115, updated on 21-Apr-2024

Summary

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Official Symbol
Bean1provided by MGI
Official Full Name
brain expressed, associated with Nedd4, 1provided by MGI
Primary source
MGI:MGI:1929597
See related
Ensembl:ENSMUSG00000031872 AllianceGenome:MGI:1929597
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bean
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 31. Orthologous to human BEAN1 (brain expressed associated with NEDD4 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 7.0), testis adult (RPKM 5.9) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (104897110..104945730)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104170379..104219098)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53450 Neighboring gene STARR-positive B cell enhancer ABC_E6675 Neighboring gene predicted gene, 29682 Neighboring gene cadherin 5 Neighboring gene STARR-positive B cell enhancer ABC_E8849 Neighboring gene predicted gene 10631 Neighboring gene predicted gene 45750 Neighboring gene STARR-positive B cell enhancer ABC_E9738 Neighboring gene thymidine kinase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Jolliffe CN, et al. Biochem J, 2000 Nov 1. PMID 11042109, Free PMC Article
  2. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
  3. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
  4. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC169808

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein BEAN1
Names
brain-expressed protein associating with Nedd4
protein BEAN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001141922.2 → NP_001135394.1  protein BEAN1 isoform a

    See identical proteins and their annotated locations for NP_001135394.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC115718, AC132390
    Consensus CDS
    CCDS52645.1
    UniProtKB/TrEMBL
    E9PVP2
    Related
    ENSMUSP00000129403.2, ENSMUST00000171018.8

  2. NM_001141924.2 → NP_001135396.1  protein BEAN1 isoform b

    See identical proteins and their annotated locations for NP_001135396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    AC115718, AC132390
    Consensus CDS
    CCDS52646.1
    UniProtKB/Swiss-Prot
    Q9EQG5
    Related
    ENSMUSP00000090931.6, ENSMUST00000093245.13

  3. NM_001141925.2 → NP_001135397.1  protein BEAN1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks alternate in-frame exons in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform c has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC115718, AC132390
    Consensus CDS
    CCDS52647.1
    UniProtKB/TrEMBL
    E9Q314
    Related
    ENSMUSP00000132056.2, ENSMUST00000164076.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    104897110..104945730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531267.5 → XP_006531330.1  protein BEAN1 isoform X5

    See identical proteins and their annotated locations for XP_006531330.1

    UniProtKB/TrEMBL
    B2RR23

  2. XM_030243708.2 → XP_030099568.1  protein BEAN1 isoform X9

    Related
    ENSMUSP00000148283.2, ENSMUST00000213077.2

  3. XM_006531265.5 → XP_006531328.1  protein BEAN1 isoform X2

  4. XM_006531264.5 → XP_006531327.1  protein BEAN1 isoform X1

    See identical proteins and their annotated locations for XP_006531327.1

    UniProtKB/TrEMBL
    E9PVP2

  5. XM_011248484.4 → XP_011246786.1  protein BEAN1 isoform X7

  6. XM_011248483.3 → XP_011246785.1  protein BEAN1 isoform X6

  7. XM_011248482.3 → XP_011246784.1  protein BEAN1 isoform X4

  8. XM_030243707.2 → XP_030099567.1  protein BEAN1 isoform X8

  9. XM_006531266.4 → XP_006531329.1  protein BEAN1 isoform X3

  10. XM_006531270.1 → XP_006531333.1  protein BEAN1 isoform X9

    See identical proteins and their annotated locations for XP_006531333.1

    UniProtKB/Swiss-Prot
    Q9EQG5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQG5.2 GenPept UniProtKB/Swiss-Prot:Q9EQG5

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