Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irak1bp1provided by MGI
Official Full Name: interleukin-1 receptor-associated kinase 1 binding protein 1provided by MGI
Primary source: MGI:MGI:1929475
See related: Ensembl:ENSMUSG00000032251 AllianceGenome:MGI:1929475
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aabp3; Aip70; Simpl; 4921528N06Rik
Summary: Acts upstream of or within I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and skeletal muscle. Orthologous to human IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 11.5), CNS E18 (RPKM 10.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E2; 9 45.16 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (82711859..82729741)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (82829806..82847688)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIMPL functions as a TNFalpha-dependent p65 co-activator by facilitating the recruitment of MED1 to p65 containing transcriptional complexes to control the expression of a subset of TNFalpha-induced genes.
Title: SIMPL enhancement of tumor necrosis factor-α dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function.
IRAK1BP1 functions through its effects on NF-kappaB as a molecular switch to bias innate immune pathways toward the resolution of inflammation
Title: IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50.
Signals transduced through the tumor necrosis factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that interacts with mouse pelle-like kinase) pathway support hematopoietic progenitor cell survival, growth and differentiation
Title: Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors.
IRAK1BP1 regulates transcription of a specific subset of Toll-like receptor responsive genes, producing an overall antiinflammatory profile
Title: Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1.
Hsp70/Hsc70 bind the intrinsically disordered amino-terminal region of SIMPL to stabilize the protein and thereby regulate its activity.
Title: The disordered amino-terminus of SIMPL interacts with members of the 70-kDa heat-shock protein family.
TNF-alpha activation of NF-kappaB dependent-gene expression requires nuclear relocalization of p65 as well as nuclear relocalization of SIMPL, generating a TNF-alpha-specific induction of gene expression.
Title: Tumor necrosis factor alpha induction of NF-kappaB requires the novel coactivator SIMPL.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (3)

General gene information

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Markers

D19250 (e-PCR)
- UniSTS:124796

AI851240 (e-PCR)
- UniSTS:179945

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase 1-binding protein 1

Names: Acta binding protein 3; Acta-binding protein 70; IRAK1-binding protein 1; Plk-interacting protein; signaling molecule that associates with the mouse pelle-like kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168240.1 → NP_001161712.1 interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_001161712.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK014712, AK045436, BY719456

Consensus CDS

CCDS52871.1

UniProtKB/TrEMBL

G5E885

Related

ENSMUSP00000034783.5, ENSMUST00000034783.6

Conserved Domains (1) summary

pfam04402
Location:55 → 174

SIMPL; Protein of unknown function (DUF541)
NM_022986.4 → NP_075362.3 interleukin-1 receptor-associated kinase 1-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_075362.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK045436, BY719456

Consensus CDS

CCDS23372.1

UniProtKB/Swiss-Prot

Q8BT82, Q8C645, Q9CRM0, Q9CV21, Q9CX27, Q9ESJ7, Q9JK12

Related

ENSMUSP00000108871.3, ENSMUST00000113245.9

Conserved Domains (1) summary

pfam04402
Location:55 → 196

SIMPL; Protein of unknown function (DUF541)