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Zfand6 zinc finger, AN1-type domain 6 [ Mus musculus (house mouse) ]

Gene ID: 65098, updated on 5-Mar-2024

Summary

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Official Symbol
Zfand6provided by MGI
Official Full Name
zinc finger, AN1-type domain 6provided by MGI
Primary source
MGI:MGI:1929510
See related
Ensembl:ENSMUSG00000030629 AllianceGenome:MGI:1929510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Awp1; Za20d3; 3110005P07Rik
Summary
Enables polyubiquitin modification-dependent protein binding activity. Involved in protein targeting to peroxisome. Acts upstream of or within signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including central nervous system; lower urinary tract; and retina. Orthologous to human ZFAND6 (zinc finger AN1-type containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 49.8), bladder adult (RPKM 34.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 48.36 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (84264253..84339224, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (84615045..84690016, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cortexin domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr7:91742914-91743215 Neighboring gene STARR-seq mESC enhancer starr_19439 Neighboring gene fumarylacetoacetate hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E2830 Neighboring gene RIKEN cDNA 2610206C17 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:91838324-91838625 Neighboring gene STARR-seq mESC enhancer starr_19440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:91898346-91898547 Neighboring gene STARR-positive B cell enhancer mm9_chr7:91898675-91898976 Neighboring gene transformation related protein 63 regulated like, pseudogene 1 Neighboring gene predicted gene, 57784 Neighboring gene predicted gene, 53362

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase. Miyata N, et al. Traffic, 2012 Jan. PMID 21980954
  2. Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo. Duan W, et al. Gene, 2000 Oct 3. PMID 11054541
  3. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AWP1 is a novel cofactor of Pex6 involved in the regulation of Pex5 export during peroxisome biogenesis.
    Title: AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 6
Names
associated with PRK1 protein
associated with Prkcl1
zinc finger A20 domain-containing protein 3
zinc finger, A20 domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360577.1 → NP_001347506.1  AN1-type zinc finger protein 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC132619, AV471887, CJ088967
    Consensus CDS
    CCDS21419.1
    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Related
    ENSMUSP00000146878.2, ENSMUST00000209165.2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  2. NM_001360578.1 → NP_001347507.1  AN1-type zinc finger protein 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC132619
    Consensus CDS
    CCDS21419.1
    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Related
    ENSMUSP00000146518.2, ENSMUST00000209117.2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  3. NM_001360579.1 → NP_001347508.1  AN1-type zinc finger protein 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC132619
    Consensus CDS
    CCDS21419.1
    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Related
    ENSMUSP00000147192.2, ENSMUST00000208782.2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  4. NM_001360580.1 → NP_001347509.1  AN1-type zinc finger protein 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC132619
    Consensus CDS
    CCDS21419.1
    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Related
    ENSMUSP00000135968.2, ENSMUST00000178385.9
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  5. NM_001360581.1 → NP_001347510.1  AN1-type zinc finger protein 6 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC132619, BY307690
    Consensus CDS
    CCDS21419.1
    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Related
    ENSMUSP00000146682.2, ENSMUST00000207865.2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  6. NM_001360582.1 → NP_001347511.1  AN1-type zinc finger protein 6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    AC132619, CJ088967
    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  7. NM_022985.7 → NP_075361.2  AN1-type zinc finger protein 6 isoform a

    See identical proteins and their annotated locations for NP_075361.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same isoform (a).
    Source sequence(s)
    AC132619
    Consensus CDS
    CCDS21419.1
    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Related
    ENSMUSP00000069228.3, ENSMUST00000069537.3
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    84264253..84339224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508110.3 → XP_006508173.1  AN1-type zinc finger protein 6 isoform X3

    See identical proteins and their annotated locations for XP_006508173.1

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  2. XM_030242873.2 → XP_030098733.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  3. XM_030242871.2 → XP_030098731.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  4. XM_036153333.1 → XP_036009226.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  5. XM_030242867.2 → XP_030098727.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  6. XM_030242866.2 → XP_030098726.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  7. XM_030242870.2 → XP_030098730.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  8. XM_030242875.1 → XP_030098735.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  9. XM_030242872.2 → XP_030098732.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  10. XM_030242876.2 → XP_030098736.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  11. XM_030242869.2 → XP_030098729.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  12. XM_036153331.1 → XP_036009224.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  13. XM_036153330.1 → XP_036009223.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  14. XM_030242868.1 → XP_030098728.1  AN1-type zinc finger protein 6 isoform X1

    UniProtKB/Swiss-Prot
    Q9DCH6, Q9ER79
    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:164 → 201
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  15. XM_030242874.1 → XP_030098734.1  AN1-type zinc finger protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:163 → 200
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger

  16. XM_030242877.1 → XP_030098737.1  AN1-type zinc finger protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A140LIM2
    Conserved Domains (2) summary
    smart00154
    Location:149 → 186
    ZnF_AN1; AN1-like Zinc finger
    pfam01754
    Location:12 → 34
    zf-A20; A20-like zinc finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCH6.1 GenPept UniProtKB/Swiss-Prot:Q9DCH6

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