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MRPL11 mitochondrial ribosomal protein L11 [ Homo sapiens (human) ]

Gene ID: 65003, updated on 5-Mar-2024

Summary

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Official Symbol
MRPL11provided by HGNC
Official Full Name
mitochondrial ribosomal protein L11provided by HGNC
Primary source
HGNC:HGNC:14042
See related
Ensembl:ENSG00000174547 MIM:611826; AllianceGenome:HGNC:14042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L11MT; uL11m; CGI-113; MRP-L11
Summary
This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in colon (RPKM 11.1), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66435075..66438848, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66431420..66435193, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66202546..66206319, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66181037-66181555 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66181556-66182074 Neighboring gene neuronal PAS domain protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66185208-66185708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66185709-66186209 Neighboring gene Sharpr-MPRA regulatory region 12876 Neighboring gene small nucleolar RNA SNORA43 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5044 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:66219904-66220097 Neighboring gene chromosome 5 open reading frame 63 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66232341-66232842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66232843-66233342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3594 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66243741-66244561 Neighboring gene DPP3 divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli. Han MJ, et al. Protein Expr Purif, 2011 Jul. PMID 21453772
  2. GRSF1 regulates RNA processing in mitochondrial RNA granules. Jourdain AA, et al. Cell Metab, 2013 Mar 5. PMID 23473034, Free PMC Article
  3. FBXO22 degrades nuclear PTEN to promote tumorigenesis. Ge MK, et al. Nat Commun, 2020 Apr 6. PMID 32249768, Free PMC Article
  4. The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling. Cui H, et al. Nat Commun, 2022 Aug 9. PMID 35945219, Free PMC Article
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634

See all (96) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein L11 (MRPL11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with mitochondrial ribosomal protein L11 (MRPL11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein uL11m
Names
39S ribosomal protein L11, mitochondrial
mitochondrial large ribosomal subunit protein uL11m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016050.5 → NP_057134.1  large ribosomal subunit protein uL11m isoform a

    See identical proteins and their annotated locations for NP_057134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK290084, AL519939, BU597133, BU678208
    Consensus CDS
    CCDS8139.1
    UniProtKB/Swiss-Prot
    A6NLT0, A8K219, Q32P46, Q96Q73, Q9Y3B7
    UniProtKB/TrEMBL
    Q53G19
    Related
    ENSP00000308897.7, ENST00000310999.11
    Conserved Domains (1) summary
    cd00349
    Location:20 → 155
    Ribosomal_L11; Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal ...

  2. NM_170738.4 → NP_733934.1  large ribosomal subunit protein uL11m isoform b

    See identical proteins and their annotated locations for NP_733934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in an isoform (b) that lacks an internal segment of sequence, compared to isoform a.
    Source sequence(s)
    AP002748
    Consensus CDS
    CCDS44655.1
    UniProtKB/TrEMBL
    Q53G19
    Related
    ENSP00000415356.2, ENST00000430466.6
    Conserved Domains (1) summary
    cd00349
    Location:16 → 129
    Ribosomal_L11; Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal ...

  3. NM_170739.4 → NP_733935.1  large ribosomal subunit protein uL11m isoform c

    See identical proteins and their annotated locations for NP_733935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an additional exon compared to variant 1, which results in a frameshift. It encodes an isoform (c) that is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK290084, AL519939, BQ020382, BU597133, BU678208
    Consensus CDS
    CCDS8140.1
    UniProtKB/TrEMBL
    Q53G19
    Related
    ENSP00000329630.4, ENST00000329819.4
    Conserved Domains (1) summary
    smart00649
    Location:20 → 156
    RL11; Ribosomal protein L11/L12

RNA

  1. NR_120588.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP002748

  2. NR_120589.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site at the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP002748

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    66435075..66438848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018135.3 → XP_016873624.1  large ribosomal subunit protein uL11m isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    66431420..66435193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369669.1 → XP_054225644.1  large ribosomal subunit protein uL11m isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y3B7.1 GenPept UniProtKB/Swiss-Prot:Q9Y3B7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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