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LINC00273 long intergenic non-protein coding RNA 273 [ Homo sapiens (human) ]

Gene ID: 649159, updated on 10-Oct-2023

Summary

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Official Symbol
LINC00273provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 273provided by HGNC
Primary source
HGNC:HGNC:38595
See related
Ensembl:ENSG00000256642 AllianceGenome:HGNC:38595
Gene type
ncRNA
RefSeq status
MODEL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOP; NCRNA00273
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Genomic context

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Location:
16p11.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (34158585..34159973, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (35736355..35737743, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene double homeobox 4 like 46 (pseudogene) Neighboring gene double homeobox 4 like 47 (pseudogene) Neighboring gene ReSE screen-validated silencer GRCh37_chr16:33948294-33948529 Neighboring gene RNA, 18S ribosomal pseudogene Neighboring gene RNA, 5.8S ribosomal pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness. Jana S, et al. Oncotarget, 2017 Dec 15. PMID 29299144, Free PMC Article
  2. Cloning and sequencing of a cDNA encoding for a protein specifically expressed in human testis, ovary and placenta. Naz RK, et al. Front Biosci, 2004 Sep 1. PMID 15353267
  3. LncTIC1 interacts with β-catenin to drive liver TIC self-renewal and liver tumorigenesis. Chen Z, et al. Cancer Lett, 2018 Aug 28. PMID 29778568
  4. Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway. Chen J, et al. Clin Transl Med, 2021 Sep. PMID 34586722, Free PMC Article
  5. TGFβ mediated LINC00273 upregulation sponges mir200a-3p and promotes invasion and metastasis by activating ZEB1. Sarkar A, et al. J Cell Physiol, 2020 Oct. PMID 32017082

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
    Title: Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
  2. LINC00273 modulates lung cancer metastasis through ZEB1 regulation. TGF-beta induced invasion and metastasis of A549 cells is accompanied by an upregulation of LINC00273 expression. LINC00273 upregulation makes ZEB1 free by sponging miR200a-3p and enhancing TGF-beta induced metastasis.
    Title: TGFβ mediated LINC00273 upregulation sponges mir200a-3p and promotes invasion and metastasis by activating ZEB1.
  3. LINC00273 is involved in regulating cancer cell metastasis, migration and invasion. Its expression is correlated with degree of cellular dedifferentiation. LINC00273 harbors a unique (4n-1) parallel G-Quadruplex structure in its promoter which makes it a prominent target of anti-metastatic drug M2.
    Title: LINCRNA00273 promotes cancer metastasis and its G-Quadruplex promoter can serve as a novel target to inhibit cancer invasiveness.
  4. Study found that lncTIC1 is highly expressed in liver tumor-initiating cells (TICs) and required for the self-renewal of liver TICs. LncTIC1 drove liver TIC self-renewal through Wnt/beta-catenin signaling. LncTIC1 interacted with the N terminal of beta-catenin and inhibited the phosphorylation of beta-catenin, finally maintaining the stability of beta-catenin to drive the activation of Wnt/beta-catenin signaling and li...
    Title: LncTIC1 interacts with β-catenin to drive liver TIC self-renewal and liver tumorigenesis.
  5. T17 (TOP) is a protein specifically expressed in human testis, ovary and placenta
    Title: Cloning and sequencing of a cDNA encoding for a protein specifically expressed in human testis, ovary and placenta.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    34158585..34159973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004837543.1 RNA Sequence

    Related
    ENST00000539813.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    35736355..35737743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007086565.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040069.1: Suppressed sequence

    Description
    NM_001040069.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
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