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NIBAN2 niban apoptosis regulator 2 [ Homo sapiens (human) ]

Gene ID: 64855, updated on 11-Apr-2024

Summary

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Official Symbol
NIBAN2provided by HGNC
Official Full Name
niban apoptosis regulator 2provided by HGNC
Primary source
HGNC:HGNC:25282
See related
Ensembl:ENSG00000136830 MIM:614045; AllianceGenome:HGNC:25282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OC58; MEG-3; C9orf88; FAM129B; MINERVA; bA356B19.6
Summary
Enables transcription coactivator activity. Involved in several processes, including gonadotropin secretion; positive regulation of transcription regulatory region DNA binding activity; and regulation of cellular macromolecule biosynthetic process. Located in several cellular components, including adherens junction; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 167.0), lung (RPKM 55.7) and 20 other tissues See more
Orthologs
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Genomic context

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See NIBAN2 in Genome Data Viewer
Location:
9q34.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127505343..127579031, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139712305..139786022, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130267622..130341310, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:130211857-130212400 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130212943-130213486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29041 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29042 Neighboring gene small nucleolar RNA, H/ACA box 65 Neighboring gene ribosomal protein L12 Neighboring gene leucine rich repeat and sterile alpha motif containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130226032-130226532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130226533-130227033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130251390-130251970 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130251971-130252551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130256483-130257002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130262849-130263350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130266531-130267404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130285667-130286168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130286169-130286668 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130287309-130287861 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130293634-130294194 Neighboring gene uncharacterized LOC105376281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130314335-130314834 Neighboring gene Sharpr-MPRA regulatory region 14561 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130323322-130324026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130324732-130325436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130325437-130326140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130328804-130329344 Neighboring gene FAM129B intron CAGE-defined low expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130331508-130332048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130332049-130332588 Neighboring gene Sharpr-MPRA regulatory region 10550 Neighboring gene uncharacterized LOC124902276 Neighboring gene uncharacterized LOC124902277

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural Insight on Functional Regulation of Human MINERVA Protein. Hahn H, et al. Int J Mol Sci, 2020 Oct 31. PMID 33142954, Free PMC Article
  2. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Old WM, et al. Mol Cell, 2009 Apr 10. PMID 19362540, Free PMC Article
  3. FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding. Cheng KC, et al. EBioMedicine, 2019 Jul. PMID 31262713, Free PMC Article
  4. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. Chen S, et al. J Biol Chem, 2011 Mar 25. PMID 21148485, Free PMC Article
  5. Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Zhang X, et al. Cancer Res, 2010 Mar 15. PMID 20179190, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural Insight on Functional Regulation of Human MINERVA Protein.
    Title: Structural Insight on Functional Regulation of Human MINERVA Protein.
  2. We have demonstrated that FAM129B in cancer promotes Nrf2 activity by reducing its ubiquitination through competition with Nrf2 for Keap1 binding via its DLG and ETGE motifs. In addition, FAM129B reduces chemosensitivity by augmenting Nrf2 antioxidative signaling and confers poor prognosis in breast and lung cancer
    Title: FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding.
  3. activated EGFR phosphorylates the Y593 residue of the protein known as family with sequence similarity 129, member B (FAM129B), which is overexpressed in many types of human cancer.
    Title: EGFR phosphorylates FAM129B to promote Ras activation.
  4. The rapid induction of apoptosis in FAM129B knockdown cells was reversed by co-transfection with recombinant FAM129B, indicating that its effect on apoptosis was specific.
    Title: FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells.
  5. Phosphorylation of FAM129B has a role in controlling melanoma cell invasion.
    Title: Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13518, FLJ22151, FLJ22298, DKFZP434H0820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gonadotropin secretion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in gonadotropin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression via chromosomal CpG island demethylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
protein Niban 2
Names
family with sequence similarity 129 member B
melanoma invasion by ERK
niban-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001035534.3 → NP_001030611.1  protein Niban 2 isoform 2

    See identical proteins and their annotated locations for NP_001030611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL390116, AL445222
    Consensus CDS
    CCDS35144.1
    Related
    ENSP00000362411.3, ENST00000373314.7
    Conserved Domains (2) summary
    pfam15685
    Location:637 → 732
    GGN; Gametogenetin
    cl17171
    Location:122 → 175
    PH-like; Pleckstrin homology-like domain

  2. NM_022833.4 → NP_073744.2  protein Niban 2 isoform 1

    See identical proteins and their annotated locations for NP_073744.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL137555, BM557756, BX280720
    Consensus CDS
    CCDS35145.1
    UniProtKB/Swiss-Prot
    Q4LE55, Q5VVW6, Q5VVW7, Q96TA1, Q9BUS2, Q9NT35
    Related
    ENSP00000362409.3, ENST00000373312.4
    Conserved Domains (2) summary
    pfam15685
    Location:650 → 745
    GGN; Gametogenetin
    cl17171
    Location:135 → 188
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    127505343..127579031 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518925.2 → XP_011517227.1  protein Niban 2 isoform X2

    Conserved Domains (2) summary
    pfam15685
    Location:680 → 775
    GGN; Gametogenetin
    cl17171
    Location:165 → 218
    PH-like; Pleckstrin homology-like domain

  2. XM_005252135.3 → XP_005252192.3  protein Niban 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    139712305..139786022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96TA1.3 GenPept UniProtKB/Swiss-Prot:Q96TA1

Gene LinkOut

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