U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

FNDC4 fibronectin type III domain containing 4 [ Homo sapiens (human) ]

Gene ID: 64838, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
FNDC4provided by HGNC
Official Full Name
fibronectin type III domain containing 4provided by HGNC
Primary source
HGNC:HGNC:20239
See related
Ensembl:ENSG00000115226 MIM:611905; AllianceGenome:HGNC:20239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRCP1
Summary
Involved in response to transforming growth factor beta. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to be active in extracellular region and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 35.7), brain (RPKM 13.1) and 11 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27491883..27495200, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27534239..27537558, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27714750..27718067, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27665383-27665925 Neighboring gene keratinocyte associated protein 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27676057-27677256 Neighboring gene intraflagellar transport 172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27681686-27682885 Neighboring gene RNA, U6 small nuclear 986, pseudogene Neighboring gene glucokinase regulator Neighboring gene Sharpr-MPRA regulatory region 4379 Neighboring gene SPATA31 subfamily H member 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27788766-27789965

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes. Frühbeck G, et al. Metabolism, 2020 Jul. PMID 32407726
  2. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction. Daudon M, et al. Reproduction, 2022 May 23. PMID 35521900
  3. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes. Frühbeck G, et al. Cell Mol Immunol, 2021 Oct. PMID 34465884, Free PMC Article
  4. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Georgiadi A, et al. Nat Commun, 2021 May 20. PMID 34016966, Free PMC Article
  5. FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Bosma M, et al. Nat Commun, 2016 Apr 12. PMID 27066907, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.
    Title: FNDC4 reduces inflammation, proliferation, invasion and migration of rheumatoid synovial cells by inhibiting CCL2/ERK signaling.
  2. Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction.
    Title: Irisin and the fibronectin type III domain-containing family: structure, signaling and role in female reproduction.
  3. FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes.
    Title: FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes.
  4. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
    Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
  5. The novel adipokine FNDC4 reduces lipogenesis and increases fat browning in human visceral adipocytes.
    Title: FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes.
  6. FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
    Title: FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  9. Reports the cloning, expression and subcellular localization of the related mouse protein.
    Title: Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
EBI GWAS Catalog
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
EBI GWAS Catalog
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
EBI GWAS Catalog
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
EBI GWAS Catalog
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
EBI GWAS Catalog
New loci associated with kidney function and chronic kidney disease.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ22362

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
fibronectin type III domain-containing protein 4
Names
fibronectin type III repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022823.3 → NP_073734.1  fibronectin type III domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_073734.1

    Status: VALIDATED

    Source sequence(s)
    BC032725, DB452792
    Consensus CDS
    CCDS1756.1
    UniProtKB/Swiss-Prot
    D6W560, Q9H6D8
    Related
    ENSP00000264703.3, ENST00000264703.4
    Conserved Domains (1) summary
    cd00063
    Location:47 → 137
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27491883..27495200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264499.5 → XP_005264556.1  fibronectin type III domain-containing protein 4 isoform X2

    Related
    ENST00000491414.5
    Conserved Domains (1) summary
    cd00063
    Location:47 → 137
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_047445471.1 → XP_047301427.1  fibronectin type III domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    D6W560, Q9H6D8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27534239..27537558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343401.1 → XP_054199376.1  fibronectin type III domain-containing protein 4 isoform X2

  2. XM_054343402.1 → XP_054199377.1  fibronectin type III domain-containing protein 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6D8.1 GenPept UniProtKB/Swiss-Prot:Q9H6D8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous