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ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 6483, updated on 11-Apr-2024

Summary

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Official Symbol
ST3GAL2provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:10863
See related
Ensembl:ENSG00000157350 MIM:607188; AllianceGenome:HGNC:10863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT4B; ST3GALII; Gal-NAc6S; ST3GalA.2
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 6.9), spleen (RPKM 6.8) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (70375977..70439100, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (76187004..76250128, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70409880..70473003, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 19B Neighboring gene DDX19A divergent transcript Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:70366483-70367682 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70379806-70380424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70380425-70381042 Neighboring gene DEAD-box helicase 19A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11055 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70421141-70421825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11057 Neighboring gene uncharacterized LOC124903707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:70458653-70459478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70461771-70462462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70462463-70463152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11061 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70464537-70465228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:70467433-70467993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11063 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7673 Neighboring gene ribosomal protein S27 pseudogene 26 Neighboring gene RNA, U6 small nuclear 23, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II. Ruggiero FM, et al. Biochem J, 2015 Jul 1. PMID 25916169
  2. Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase. Saito S, et al. J Biol Chem, 2003 Jul 18. PMID 12716912
  3. Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene. Taniguchi A, et al. Biochem Biophys Res Commun, 2003 Jan 10. PMID 12504121
  4. Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II). Kim YJ, et al. Biochem Biophys Res Commun, 1996 Nov 12. PMID 8920913
  5. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation. Zhang N, et al. Blood Adv, 2022 Jul 12. PMID 35507766, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
    Title: Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
  2. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status.
    Title: Ganglioside glycosyltransferases are S-acylated at conserved cysteine residues involved in homodimerisation.
  3. This suggests that the C-terminal domain of ST3Gal-II depends on N-glycosylation to attain an optimum conformation for proper exit from the endoplasmic reticulum
    Title: Critical role of evolutionarily conserved glycosylation at Asn211 in the intracellular trafficking and activity of sialyltransferase ST3Gal-II.
  4. ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4) synthase and its increased expression level is closely related to renal carcinogenesis
    Title: Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase.
  5. Genomic structure, expression, and transcriptional regulation of ST3GALII.
    Title: Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sialyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing TAS
Traceable Author Statement
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in globoside biosynthetic process via lactosylceramide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosphingolipid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in lipid glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sialylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in viral protein processing TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
Names
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
SIAT4-B
ST3Gal II
alpha 2,3-ST 2
beta-galactoside alpha-2,3-sialyltransferase 2
monosialoganglioside sialyltransferase
sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase)
NP_008858.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046942.1 RefSeqGene

    Range
    5001..64654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006927.4 → NP_008858.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

    See identical proteins and their annotated locations for NP_008858.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK127322, BC036777
    Consensus CDS
    CCDS10890.1
    UniProtKB/Swiss-Prot
    O00654, Q16842
    UniProtKB/TrEMBL
    B2R7K8, B3KXG9
    Related
    ENSP00000345477.2, ENST00000342907.3
    Conserved Domains (1) summary
    pfam00777
    Location:95 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    70375977..70439100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    76187004..76250128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16842.1 GenPept UniProtKB/Swiss-Prot:Q16842

Gene LinkOut

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