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HS3ST6 heparan sulfate-glucosamine 3-sulfotransferase 6 [ Homo sapiens (human) ]

Gene ID: 64711, updated on 5-Mar-2024

Summary

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Official Symbol
HS3ST6provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 6provided by HGNC
Primary source
HGNC:HGNC:14178
See related
Ensembl:ENSG00000162040 MIM:619210; AllianceGenome:HGNC:14178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HAE8; 3OST6; HS3ST5; 3-OST-6
Summary
Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in glycosaminoglycan biosynthetic process. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 2.3), placenta (RPKM 0.2) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1911475..1920940, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1930559..1940903, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1961476..1968416, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 254 Neighboring gene long intergenic non-protein coding RNA 2124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1945999-1946500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1961835-1962392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1968509-1969070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1969071-1969634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1969635-1970196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1970197-1970760 Neighboring gene Sharpr-MPRA regulatory region 1858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1991100-1991989 Neighboring gene uncharacterized LOC124903625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7010 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene ribosomal protein L3 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2003405-2004394

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. Chen J, et al. Glycobiology, 2003 Nov. PMID 12907690
  2. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. Xu D, et al. Biochem J, 2005 Jan 15. PMID 15303968, Free PMC Article
  3. Characterization of a heparan sulfate 3-O-sulfotransferase-5, an enzyme synthesizing a tetrasulfated disaccharide. Mochizuki H, et al. J Biol Chem, 2003 Jul 18. PMID 12740361
  4. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. Xia G, et al. J Biol Chem, 2002 Oct 4. PMID 12138164
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Daniels RJ, et al. Hum Mol Genet, 2001 Feb 15. PMID 11157797

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1
    Title: Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Angioedema, hereditary, 8
MedGen: C5543528 OMIM: 619367 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in blastocyst hatching IEA
Inferred from Electronic Annotation
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 6
Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
heparan sulfate (glucosamine) 3-O-sulfotransferase 6
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B like
NP_001009606.3
XP_011520910.1
XP_011520911.1
XP_047290443.1
XP_054169666.1
XP_054169667.1
XP_054169668.1
XP_054185164.1
XP_054185165.1
XP_054185166.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009606.4 → NP_001009606.3  heparan sulfate glucosamine 3-O-sulfotransferase 6

    See identical proteins and their annotated locations for NP_001009606.3

    Status: VALIDATED

    Source sequence(s)
    AL031723, CK300523, DY654407
    Consensus CDS
    CCDS45381.2
    UniProtKB/Swiss-Prot
    Q96QI5, Q96RX7
    Related
    ENSP00000416741.3, ENST00000454677.3
    Conserved Domains (1) summary
    pfam00685
    Location:91 → 326
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1911475..1920940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522608.3 → XP_011520910.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

    See identical proteins and their annotated locations for XP_011520910.1

    Conserved Domains (1) summary
    pfam00685
    Location:26 → 201
    Sulfotransfer_1; Sulfotransferase domain

  2. XM_047434487.1 → XP_047290443.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

  3. XM_011522609.2 → XP_011520911.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

    See identical proteins and their annotated locations for XP_011520911.1

    Conserved Domains (1) summary
    pfam00685
    Location:11 → 186
    Sulfotransfer_1; Sulfotransferase domain

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187609.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    41605..51070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329189.1 → XP_054185164.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

  2. XM_054329190.1 → XP_054185165.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

  3. XM_054329191.1 → XP_054185166.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1930559..1940903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313691.1 → XP_054169666.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

  2. XM_054313692.1 → XP_054169667.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

  3. XM_054313693.1 → XP_054169668.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96QI5.2 GenPept UniProtKB/Swiss-Prot:Q96QI5

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