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ZNF723 zinc finger protein 723 [ Homo sapiens (human) ]

Gene ID: 646864, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF723provided by HGNC
Official Full Name
zinc finger protein 723provided by HGNC
Primary source
HGNC:HGNC:32286
See related
Ensembl:ENSG00000268696 AllianceGenome:HGNC:32286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF723P
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (22812218..22858667)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (22954249..23000692)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23015093..23041469)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 87 pseudogene Neighboring gene zinc finger protein 99 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:22961599-22962098 Neighboring gene BCL2 interacting protein 3 pseudogene 34 Neighboring gene BCL2 interacting protein 3 pseudogene 35 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23053617-23054388 Neighboring gene vomeronasal 1 receptor 88 pseudogene Neighboring gene uncharacterized LOC105372332

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A scan for positively selected genes in the genomes of humans and chimpanzees. Nielsen R, et al. PLoS Biol, 2005 Jun. PMID 15869325, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 723

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349726.2 → NP_001336655.1  zinc finger protein 723

    Status: VALIDATED

    Source sequence(s)
    AC008626, AC022145
    Consensus CDS
    CCDS86735.1
    UniProtKB/Swiss-Prot
    P0DPD5
    Related
    ENSP00000494306.1, ENST00000600766.3
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:156 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    22812218..22858667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439223.1 → XP_047295179.1  zinc finger protein 723 isoform X1

    UniProtKB/Swiss-Prot
    P0DPD5

  2. XM_024451652.2 → XP_024307420.1  zinc finger protein 723 isoform X1

    UniProtKB/Swiss-Prot
    P0DPD5
    Conserved Domains (3) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:156 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047439225.1 → XP_047295181.1  zinc finger protein 723 isoform X2

  4. XM_047439224.1 → XP_047295180.1  zinc finger protein 723 isoform X1

    UniProtKB/Swiss-Prot
    P0DPD5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    22954249..23000692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321775.1 → XP_054177750.1  zinc finger protein 723 isoform X1

    UniProtKB/Swiss-Prot
    P0DPD5

  2. XM_054321774.1 → XP_054177749.1  zinc finger protein 723 isoform X1

    UniProtKB/Swiss-Prot
    P0DPD5

  3. XM_054321777.1 → XP_054177752.1  zinc finger protein 723 isoform X2

  4. XM_054321776.1 → XP_054177751.1  zinc finger protein 723 isoform X1

    UniProtKB/Swiss-Prot
    P0DPD5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_029131.2: Suppressed sequence

    Description
    NG_029131.2: This RefSeq was removed because it is now thought that this locus is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DPD5.1 GenPept UniProtKB/Swiss-Prot:P0DPD5

Gene LinkOut

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Molecular Biology Databases
Research Materials