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HHIP-AS1 HHIP antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 646576, updated on 10-Oct-2023

Summary

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Official Symbol
HHIP-AS1provided by HGNC
Official Full Name
HHIP antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:44182
See related
Ensembl:ENSG00000248890 AllianceGenome:HGNC:44182
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHAS1
Expression
Broad expression in lung (RPKM 5.8), prostate (RPKM 2.1) and 16 other tissues See more
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Genomic context

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See HHIP-AS1 in Genome Data Viewer
Location:
4q31.21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (144642916..144646019, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (147960290..147963411, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (145564068..145567171, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377462 Neighboring gene NANOG hESC enhancer GRCh37_chr4:145209206-145209729 Neighboring gene VISTA enhancer hs906 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:145312958-145313150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21957 Neighboring gene keratin 18 pseudogene 51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:145567273-145567838 Neighboring gene NANOG hESC enhancer GRCh37_chr4:145569079-145569667 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:145570690-145571326 Neighboring gene uncharacterized LOC124900791 Neighboring gene hedgehog interacting protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:145720303-145720804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:145720805-145721304 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:145729541-145730082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:145757647-145758148 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Bartl J, et al. Nat Commun, 2022 Jul 13. PMID 35831316, Free PMC Article
  2. A novel long noncoding RNA HHIP-AS1 suppresses hepatocellular carcinoma progression through stabilizing HHIP mRNA. Bo C, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31604528
  3. Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2. Yang Y, et al. Crit Rev Eukaryot Gene Expr, 2022. PMID 36374812
  4. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. Wilk JB, et al. PLoS Genet, 2009 Mar. PMID 19300500, Free PMC Article
  5. IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA. Ye G, et al. Clin Transl Med, 2021 Jun. PMID 34185419, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.
    Title: Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.
  2. The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
    Title: The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
  3. HHIP-AS1 is down-regulated in the hepatocellular carcinoma tissues and predicts poor prognosis.HHIP-AS1 represses hepatocellular carcinoma progression by promoting HHIP expression.
    Title: A novel long noncoding RNA HHIP-AS1 suppresses hepatocellular carcinoma progression through stabilizing HHIP mRNA.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
IREB2 and GALC are Associated with Pulmonary Artery Enlargement in Chronic Obstructive Pulmonary Disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • HHIP antisense RNA 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_037595.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC039450, BX452340
    Related
    ENST00000508269.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    144642916..144646019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    147960290..147963411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases