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LINC00607 long intergenic non-protein coding RNA 607 [ Homo sapiens (human) ]

Gene ID: 646324, updated on 24-Mar-2024

Summary

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Official Symbol
LINC00607provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 607provided by HGNC
Primary source
HGNC:HGNC:43944
See related
Ensembl:ENSG00000235770 AllianceGenome:HGNC:43944
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
2q35
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (215611563..215843536, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216097003..216328916, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216476286..216708259, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12300 Neighboring gene fibronectin 1 Neighboring gene uncharacterized LOC102724849 Neighboring gene Sharpr-MPRA regulatory region 5619 Neighboring gene FN1 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216392847-216394046 Neighboring gene uncharacterized LOC102724861 Neighboring gene Sharpr-MPRA regulatory region 4559 Neighboring gene NANOG hESC enhancer GRCh37_chr2:216491401-216491902 Neighboring gene uncharacterized LOC124906139 Neighboring gene long intergenic non-protein coding RNA 1614 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:216627282-216628481 Neighboring gene Sharpr-MPRA regulatory region 2478 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17075 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17076 Neighboring gene uncharacterized LOC105373870 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216786644-216787283 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:216787284-216787924 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:216792334-216792860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17079 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:216877329-216878096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17082 Neighboring gene melanoregulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17083 Neighboring gene peroxisomal trans-2-enoyl-CoA reductase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis. Dong S, et al. J Gene Med, 2023 Apr. PMID 36740760
  2. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function. Boos F, et al. Basic Res Cardiol, 2023 Jan 26. PMID 36700983, Free PMC Article
  3. Vascular Regulation by Super Enhancer-Derived LINC00607. Sriram K, et al. Front Cardiovasc Med, 2022. PMID 35837599, Free PMC Article
  4. Long non-coding RNA LINC00607 silencing exerts antioncogenic effects on thyroid cancer through the CASP9 Promoter methylation. Li L, et al. J Cell Mol Med, 2021 Aug. PMID 34232553, Free PMC Article
  5. Genome-wide association study of smoking behaviours among Bangladeshi adults. Argos M, et al. J Med Genet, 2014 May. PMID 24665060, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis.
    Title: MYC-activated LINC00607 promotes hepatocellular carcinoma progression by regulating the miR-584-3p/ROCK1 axis.
  2. The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
    Title: The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Clone Names

  • AC122136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_037195.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012668, AK124897
    Related
    ENST00000445174.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    215611563..215843536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    216097003..216328916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials