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LACTBL1 lactamase beta like 1 [ Homo sapiens (human) ]

Gene ID: 646262, updated on 5-Mar-2024

Summary

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Official Symbol
LACTBL1provided by HGNC
Official Full Name
lactamase beta like 1provided by HGNC
Primary source
HGNC:HGNC:35445
See related
Ensembl:ENSG00000215906 AllianceGenome:HGNC:35445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
1p36.12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (22953043..22972866, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (22778822..22798628, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23279536..23299359, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene EPH receptor B2 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23191518-23191863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:23203195-23203794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23206043-23206947 Neighboring gene uncharacterized LOC124903874 Neighboring gene microRNA 4253 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23216005-23216210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23251233-23251733 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23256871-23257055 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23287810-23287985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:23290925-23291425 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:23336854-23338053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23345765-23346452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23346453-23347138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 356 Neighboring gene testis expressed 46 Neighboring gene lysine demethylase 1A Neighboring gene microRNA 3115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
putative beta-lactamase-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289974.2 → NP_001276903.1  putative beta-lactamase-like 1

    Status: VALIDATED

    Source sequence(s)
    AL035704
    Consensus CDS
    CCDS90879.1
    UniProtKB/Swiss-Prot
    A8MY62
    UniProtKB/TrEMBL
    H0Y608
    Related
    ENSP00000402297.3, ENST00000426928.7
    Conserved Domains (1) summary
    pfam00144
    Location:87 → 411
    Beta-lactamase; Beta-lactamase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    22953043..22972866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    22778822..22798628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MY62.2 GenPept UniProtKB/Swiss-Prot:A8MY62

Gene LinkOut

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