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Ndst4 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 [ Mus musculus (house mouse) ]

Gene ID: 64580, updated on 11-Apr-2024

Summary

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Official Symbol
Ndst4provided by MGI
Official Full Name
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4provided by MGI
Primary source
MGI:MGI:1932545
See related
Ensembl:ENSMUSG00000027971 AllianceGenome:MGI:1932545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930439H17Rik
Summary
Enables deacetylase activity and sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including nervous system. Orthologous to human NDST4 (N-deacetylase and N-sulfotransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.2), testis adult (RPKM 1.9) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 G1; 3 54.68 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (125197678..125522550)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (125404029..125728351)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_08921 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35237 Neighboring gene STARR-seq mESC enhancer starr_08922 Neighboring gene predicted gene, 35186 Neighboring gene STARR-seq mESC enhancer starr_08923 Neighboring gene predicted gene, 40145 Neighboring gene UDP galactosyltransferase 8A Neighboring gene STARR-seq mESC enhancer starr_08924 Neighboring gene STARR-seq mESC enhancer starr_08925 Neighboring gene STARR-seq mESC enhancer starr_08928 Neighboring gene predicted gene, 40146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4. Jao TM, et al. Oncotarget, 2016 Dec 20. PMID 27793051, Free PMC Article
  2. Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. Dagälv A, et al. J Biol Chem, 2011 Dec 30. PMID 22049073, Free PMC Article
  3. Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites. Grobe K, et al. J Biol Chem, 2002 Aug 23. PMID 12070138
  4. FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling. Liu C, et al. Development, 2013 Nov. PMID 24067353, Free PMC Article
  5. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study revealed the involvement of Ndst4 in the development and homeostasis of colonic epithelium
    Title: Alteration of colonic epithelial cell differentiation in mice deficient for glucosaminyl N-deacetylase/N-sulfotransferase 4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
Names
N-HSST 4
N-deacetylase/N-sulfotransferase 4
N-heparan sulfate sulfotransferase 4
NDST-4
glucosaminyl N-deacetylase/N-sulfotransferase 4
NP_072087.2
XP_006501922.1
XP_006501923.1
XP_011238491.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022565.3 → NP_072087.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

    See identical proteins and their annotated locations for NP_072087.2

    Status: VALIDATED

    Source sequence(s)
    AC111141, AC140797, AC164153
    Consensus CDS
    CCDS17820.1
    UniProtKB/Swiss-Prot
    D3Z1R7, Q9EQW8
    Related
    ENSMUSP00000133341.3, ENSMUST00000173932.8
    Conserved Domains (2) summary
    pfam00685
    Location:594 → 845
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:20 → 505
    HSNSD; heparan sulfate-N-deacetylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    125197678..125522550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501859.2 → XP_006501922.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam12062
    Location:21 → 505
    HSNSD; heparan sulfate-N-deacetylase

  2. XM_011240189.2 → XP_011238491.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X2

    Conserved Domains (1) summary
    pfam12062
    Location:21 → 505
    HSNSD; heparan sulfate-N-deacetylase

  3. XM_006501860.2 → XP_006501923.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 isoform X3

    Conserved Domains (2) summary
    pfam00685
    Location:215 → 466
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:1 → 126
    HSNSD; heparan sulfate-N-deacetylase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQW8.2 GenPept UniProtKB/Swiss-Prot:Q9EQW8

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