WFDC21P WAP four-disulfide core domain 21, pseudogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: WFDC21Pprovided by HGNC
Official Full Name: WAP four-disulfide core domain 21, pseudogeneprovided by HGNC
Primary source: HGNC:HGNC:50357
See related: Ensembl:ENSG00000293515 MIM:615772; AllianceGenome:HGNC:50357
Gene type: pseudo
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LNCDC; lnc-DC; linc-DC
Summary: Predicted to enable enzyme activator activity. Predicted to act upstream of or within response to lipopolysaccharide; response to tumor necrosis factor; and white fat cell differentiation. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in esophagus (RPKM 17.0), skin (RPKM 14.1) and 7 other tissues See more
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Genomic context

Location:: 17q23.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (60083566..60088467, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (60952521..60957422, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (58160927..58165828, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer.
Title: A new candidate oncogenic lncRNA derived from pseudogene WFDC21P promotes tumor progression in gastric cancer.
miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation.
Title: miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation.
Expression Analysis of Long Non-coding RNA Lnc-DC in HLA-DRB1*15:01-Negative Patients with Multiple Sclerosis: A Probable Cause for Gender Differences in Multiple Sclerosis Susceptibility?
Title: Expression Analysis of Long Non-coding RNA Lnc-DC in HLA-DRB1*15:01-Negative Patients with Multiple Sclerosis: A Probable Cause for Gender Differences in Multiple Sclerosis Susceptibility?
Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis.
Title: Nur77-activated lncRNA WFDC21P attenuates hepatocarcinogenesis via modulating glycolysis.
A significant increase in expression of MALAT1 in a secondary progressive multiple sclerosis subgroup compared with controls was noted, while significant elevation of lnc-DC was demonstrated in relapsing remitting multiple sclerosis subtype, compared with normal controls.
Title: LncRNAs, MALAT1 and lnc-DC as potential biomarkers for multiple sclerosis diagnosis.
Lnc-DC is important in regulating the growth, apoptosis, and immune response of dendritic cells mediated by TLR9/STAT3 signaling, and was also activated by hepatitis B virus.
Title: Lnc-DC regulates cellular turnover and the HBV-induced immune response by TLR9/STAT3 signaling in dendritic cells.
Knockdown of LncDQ induced inhibition of cell proliferation, migration, and invasion in vitro and in vivo and regulated the epithelial-mesenchymal transition pathway by interacting with EZH2, to epigenetically repress the expression of E-cadherin in HCC cells.
Title: Upregulation of LncDQ is Associated with Poor Prognosis and Promotes Tumor Progression via Epigenetic Regulation of the EMT Pathway in HCC.
Our findings suggested the hypothesis that the overexpression of lnc-DC acts through the p-STAT3 pathway to induce the over-maturation of decidual DCs in preeclampsia patients.
Title: Lnc-DC mediates the over-maturation of decidual dendritic cells and induces the increase in Th1 cells in preeclampsia.
Plasma levels of long non-coding RNAs GAS5 and lnc-DC were significantly decreased compared with healthy controls.
Title: Identification of long non-coding RNAs GAS5, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus.
work identifies STAT3 binding long noncoding RNA lnc-DC (LOC645683) that regulates dendritic cell differentiation and also broadens the known mechanisms of lncRNA action
Title: The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

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General gene information

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Other Names

WDNM1-like pseudogene
lnc-dendritic cell lncRNA
long non-coding RNA, dendritic cell differentiation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.