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Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 64472, updated on 30-Mar-2024

Summary

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Official Symbol
Naa35provided by RGD
Official Full Name
N(alpha)-acetyltransferase 35, NatC auxiliary subunitprovided by RGD
Primary source
RGD:621771
See related
Ensembl:ENSRNOG00000018417 AllianceGenome:RGD:621771
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
T4a; Mak10
Summary
Predicted to be involved in N-terminal protein amino acid acetylation; negative regulation of apoptotic process; and smooth muscle cell proliferation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of NatC complex. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 114.4), Adrenal (RPKM 104.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
17p14
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (5039897..5091916, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (5034360..5086456, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (5411479..5463898, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 153 Neighboring gene uncharacterized LOC134482661 Neighboring gene golgi membrane protein 1 Neighboring gene serine/arginine repetitive matrix protein 3-like Neighboring gene ATP/GTP binding carboxypeptidase 1 Neighboring gene uncharacterized LOC134482764

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synaptonemal complexes from DNase-treated rat pachytene chromosomes contain (GT)n and LINE/SINE sequences. Pearlman RE, et al. Genetics, 1992 Apr. PMID 1582563, Free PMC Article
  2. A novel epithelial wound-related gene is abundantly expressed in developing rat cornea and skin. Yi XJ, et al. Curr Eye Res, 2000 May. PMID 10855038
  3. Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Wenzlau JM, et al. Circ Res, 2006 Mar 31. PMID 16484612
  4. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Starheim KK, et al. Mol Cell Biol, 2009 Jul. PMID 19398576, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex IEA
Inferred from Electronic Annotation
more info
  
part_of NatC complex ISO
Inferred from Sequence Orthology
more info
  
part_of NatC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Names
RAT52
corneal wound-healing-related protein
embryonic growth-associated protein
protein MAK10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133324.2 → NP_579858.2  N-alpha-acetyltransferase 35, NatC auxiliary subunit

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q6DKG0, Q9JI01
    UniProtKB/TrEMBL
    A0A8L2R6B2, A6KAI2
    Related
    ENSRNOP00000078947.1, ENSRNOT00000108214.1
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    5039897..5091916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253526.5 → XP_006253588.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

    See identical proteins and their annotated locations for XP_006253588.1

    UniProtKB/Swiss-Prot
    Q6DKG0, Q9JI01
    UniProtKB/TrEMBL
    A0A8L2R6B2, A6KAI2
    Conserved Domains (1) summary
    pfam04112
    Location:46 → 181
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

  2. XM_006253527.4 → XP_006253589.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

    UniProtKB/TrEMBL
    A0A8L2QDG7
    Related
    ENSRNOP00000025096.3
    Conserved Domains (1) summary
    pfam04112
    Location:1 → 122
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DKG0.1 GenPept UniProtKB/Swiss-Prot:Q6DKG0

Gene LinkOut

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