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Fcamr Fc receptor, IgA, IgM, high affinity [ Mus musculus (house mouse) ]

Gene ID: 64435, updated on 25-Apr-2024

Summary

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Official Symbol
Fcamrprovided by MGI
Official Full Name
Fc receptor, IgA, IgM, high affinityprovided by MGI
Primary source
MGI:MGI:1927803
See related
Ensembl:ENSMUSG00000026415 AllianceGenome:MGI:1927803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to act upstream of or within immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in brain; cerebellum; and spinal cord. Orthologous to human FCAMR (Fc fragment of IgA and IgM receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 2.6), kidney adult (RPKM 1.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 56.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130712444..130753641)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130784706..130825903)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AA986860 Neighboring gene predicted gene 28857 Neighboring gene predicted gene 28856 Neighboring gene STARR-seq mESC enhancer starr_02205 Neighboring gene predicted gene 15848 Neighboring gene polymeric immunoglobulin receptor Neighboring gene STARR-positive B cell enhancer ABC_E9184 Neighboring gene STARR-positive B cell enhancer ABC_E9478 Neighboring gene Fc fragment of IgM receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis. Liu J, et al. Front Immunol, 2018. PMID 29459869, Free PMC Article
  2. Involvement of Fcα/μ Receptor in IgM Anti-Platelet, but Not Anti-Red Blood Cell Autoantibody Pathogenicity in Mice. Legrain S, et al. J Immunol, 2015 Nov 1. PMID 26385523
  3. Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background. Kurita N, et al. Mol Immunol, 2015 Feb. PMID 25282043
  4. Molecular characterization of the dimer formation of Fcα/μ receptor (CD351). Takagaki K, et al. Mol Immunol, 2013 Nov. PMID 23665380
  5. Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice. Honda S, et al. Proc Natl Acad Sci U S A, 2009 Jul 7. PMID 19549827, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results reveal a critical role for FcmuR in the survival and activation of marginal zone B cells and in protection against acute bacterial infection.
    Title: Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis.
  2. Toll-like receptor 4 (TLR4) requires physical and functional association with Fcalpha-mu protein (Fcalpha/muR) for its oligomer formation and interleukin-6 (IL-6) production from marginal zone (MZ) B cells.
    Title: Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling.
  3. Serum IgA production against gut-oriented antigens is negatively regulated by Fcalpha/muR on follicular dendritic cells in the F1 mice.
    Title: Increased serum IgA in Fcα/μR-deficient mice on the (129 x C57BL/6) F1 genetic background.
  4. These results suggest that Fcalpha/muR enhances, rather than suppresses, autoantibody production.
    Title: Involvement of Fcα/μR (CD351) in autoantibody production.
  5. Data suggest that Fcalpha/muR does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa.
    Title: Molecular characterization of the dimer formation of Fcα/μ receptor (CD351).
  6. A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR.
    Title: Critical role of the IgM Fc receptor in IgM homeostasis, B-cell survival, and humoral immune responses.
  7. Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR]
    Title: Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice.
  8. expressed in oligodendrocytes, their precursor cells, and myelin
    Title: Expression of Fc receptor for immunoglobulin M in oligodendrocytes and myelin of mouse central nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC129330, MGC129331

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables IgM binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune response TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor
Names
Fc IgA/IgM receptor
Fca/m receptor
fc alpha/mu receptor
mFcamR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170632.1 → NP_001164103.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139231, FJ011703
    Consensus CDS
    CCDS48353.1
    UniProtKB/Swiss-Prot
    Q2TB54
    Related
    ENSMUSP00000108096.3, ENSMUST00000112477.9
    Conserved Domains (2) summary
    cd05716
    Location:145 → 245
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:143 → 246
    IG_like; Immunoglobulin like

  2. NM_144960.2 → NP_659209.2  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_659209.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AB048834, BC110549, BC110550
    Consensus CDS
    CCDS15259.1
    UniProtKB/Swiss-Prot
    Q2TB54, Q2TB55, Q920L8, Q9EQT7
    Related
    ENSMUSP00000027670.4, ENSMUST00000027670.4
    Conserved Domains (1) summary
    cd05716
    Location:89 → 189
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130712444..130753641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529787.5 → XP_006529850.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

    See identical proteins and their annotated locations for XP_006529850.1

    UniProtKB/Swiss-Prot
    Q2TB54, Q2TB55, Q920L8, Q9EQT7
    Conserved Domains (1) summary
    cd05716
    Location:89 → 189
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

  2. XM_017321925.3 → XP_017177414.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2

    UniProtKB/Swiss-Prot
    Q2TB54, Q2TB55, Q920L8, Q9EQT7
    Conserved Domains (1) summary
    cd05716
    Location:89 → 189
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

  3. XM_017321923.3 → XP_017177412.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    Conserved Domains (1) summary
    cd05716
    Location:139 → 239
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

  4. XM_017321921.2 → XP_017177410.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    Conserved Domains (1) summary
    cd05716
    Location:139 → 239
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

  5. XM_017321922.2 → XP_017177411.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    Conserved Domains (1) summary
    cd05716
    Location:139 → 239
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

  6. XM_017321924.2 → XP_017177413.1  high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X1

    Conserved Domains (1) summary
    cd05716
    Location:139 → 239
    Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TB54.2 GenPept UniProtKB/Swiss-Prot:Q2TB54

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