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TMEM267 transmembrane protein 267 [ Homo sapiens (human) ]

Gene ID: 64417, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM267provided by HGNC
Official Full Name
transmembrane protein 267provided by HGNC
Primary source
HGNC:HGNC:26139
See related
Ensembl:ENSG00000151881 AllianceGenome:HGNC:26139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5orf28
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 13.3), prostate (RPKM 2.9) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
5p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43444252..43484387, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43697085..43737220, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43444354..43484489, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene 60S acidic ribosomal protein P1-like Neighboring gene C-C motif chemokine ligand 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15994 Neighboring gene Sharpr-MPRA regulatory region 10963 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43483998-43484841 Neighboring gene C5orf34 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85282 Neighboring gene chromosome 5 open reading frame 34 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene uncharacterized LOC124900190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21657, MGC90226, MGC149524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 267
Names
transmembrane protein C5orf28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377394.1 → NP_001364323.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6
    Related
    ENSP00000422881.1, ENST00000512085.5

  2. NM_001377395.1 → NP_001364324.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  3. NM_001377396.1 → NP_001364325.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  4. NM_001377397.1 → NP_001364326.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  5. NM_001377398.1 → NP_001364327.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  6. NM_001377399.1 → NP_001364328.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  7. NM_001377400.1 → NP_001364329.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  8. NM_001377401.1 → NP_001364330.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6
    Related
    ENSP00000424720.1, ENST00000506860.1

  9. NM_001377402.1 → NP_001364331.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  10. NM_001377403.1 → NP_001364332.1  transmembrane protein 267

    Status: VALIDATED

    Source sequence(s)
    AC025457
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6
    Related
    ENSP00000426067.1, ENST00000500337.6

  11. NM_022483.5 → NP_071928.2  transmembrane protein 267

    See identical proteins and their annotated locations for NP_071928.2

    Status: VALIDATED

    Source sequence(s)
    AC025457, DA028175, DA035926
    Consensus CDS
    CCDS3945.1
    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6
    Related
    ENSP00000380270.3, ENST00000397080.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    43444252..43484387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417517.1 → XP_047273473.1  transmembrane protein 267 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2

  2. XM_011514075.4 → XP_011512377.1  transmembrane protein 267 isoform X1

    See identical proteins and their annotated locations for XP_011512377.1

    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
    UniProtKB/TrEMBL
    D6RAV6

  3. XM_047417516.1 → XP_047273472.1  transmembrane protein 267 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43697085..43737220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353126.1 → XP_054209101.1  transmembrane protein 267 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2

  2. XM_054353125.1 → XP_054209100.1  transmembrane protein 267 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2

  3. XM_054353124.1 → XP_054209099.1  transmembrane protein 267 isoform X1

    UniProtKB/Swiss-Prot
    B2RDA6, Q0VDI3, Q9H6Z2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VDI3.1 GenPept UniProtKB/Swiss-Prot:Q0VDI3

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