Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp4f14provided by MGI
Official Full Name: cytochrome P450, family 4, subfamily f, polypeptide 14provided by MGI
Primary source: MGI:MGI:1927669
See related: Ensembl:ENSMUSG00000024292 AllianceGenome:MGI:1927669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: cyp4f-14; 1300014O15Rik
Summary: Predicted to enable arachidonic acid binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in icosanoid metabolic process and quinone catabolic process. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver; nervous system; and testis. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 321.3), small intestine adult (RPKM 298.0) and 3 other tissues See more
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (33122331..33136353, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32903357..32917376, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

tHE TOH-omega-hydroxylase activity was exhibited by microsomes from mouse and human small intestine; murine activity was entirely due to CYP4F14.
Title: Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.
CYP4F14 is the major but not the only vitamin E-omega-hydroxylase in mice
Title: Disruption of mouse cytochrome p450 4f14 (Cyp4f14 gene) causes severe perturbations in vitamin E metabolism.
The data suggested that, in the absence of A2A adenosine receptor, omega-hydroxylase induces vasoconstriction through mitogen-activated protein kinases via upregulation of adenosine A1 receptor and protein kinase C-alpha.
Title: Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.
Catalytic activity of Cyp4fs is a novel target for modulating neuroinflammation through hydroxylation of LTB(4).
Title: Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AW108534 (e-PCR)
- UniSTS:180994

Cyp4f14 (e-PCR), detects polymorphism
- UniSTS:463010

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alkane 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables alpha-tocopherol omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid binding	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonic acid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables leukotriene-B4 20-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables tocotrienol omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene B4 catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene B4 catabolic process	ISO Inferred from Sequence Orthology more info
involved_in omega-hydroxylase P450 pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leukotriene-B4 omega-hydroxylase 3

Names: cytochrome P450 4F14; cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase); cytochrome P450-LTB-omega; leukotriene-B4 20-monooxygenase 3

NP_001191262.1

EC 1.14.14.94

NP_001191263.1

EC 1.14.14.94

NP_001191264.1

EC 1.14.14.94

NP_001191265.1

EC 1.14.14.94

NP_001344717.1

EC 1.14.14.94

NP_071879.1

EC 1.14.14.94

XP_030105833.1

EC 1.14.14.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204333.1 → NP_001191262.1 leukotriene-B4 omega-hydroxylase 3

See identical proteins and their annotated locations for NP_001191262.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AB037540, AK018676, BY705215

Consensus CDS

CCDS28621.1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Related

ENSMUSP00000157036.2, ENSMUST00000234759.2

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450
NM_001204334.1 → NP_001191263.1 leukotriene-B4 omega-hydroxylase 3

See identical proteins and their annotated locations for NP_001191263.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AB037540, AB037541, BY705215

Consensus CDS

CCDS28621.1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Related

ENSMUSP00000157006.2, ENSMUST00000235058.2

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450
NM_001204335.1 → NP_001191264.1 leukotriene-B4 omega-hydroxylase 3

See identical proteins and their annotated locations for NP_001191264.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AB037540, AI047403, CX200266

Consensus CDS

CCDS28621.1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Related

ENSMUSP00000136139.2, ENSMUST00000179434.8

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450
NM_001204336.1 → NP_001191265.1 leukotriene-B4 omega-hydroxylase 3

See identical proteins and their annotated locations for NP_001191265.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

CT033772

Consensus CDS

CCDS28621.1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450
NM_001357788.1 → NP_001344717.1 leukotriene-B4 omega-hydroxylase 3

Status: VALIDATED

Source sequence(s)

AB037540, CT033772

Consensus CDS

CCDS28621.1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450
NM_022434.2 → NP_071879.1 leukotriene-B4 omega-hydroxylase 3

See identical proteins and their annotated locations for NP_071879.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4 and 5 encode the same protein.

Source sequence(s)

AB037540, CT033772

Consensus CDS

CCDS28621.1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Related

ENSMUSP00000050478.7, ENSMUST00000054174.9

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

33122331..33136353 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249973.2 → XP_030105833.1 leukotriene-B4 omega-hydroxylase 3 isoform X1

UniProtKB/Swiss-Prot

Q52L93, Q9EP75

Conserved Domains (1) summary

pfam00067
Location:52 → 511

p450; Cytochrome P450