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Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C [ Mus musculus (house mouse) ]

Gene ID: 64380, updated on 21-Apr-2024

Summary

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Official Symbol
Ms4a4cprovided by MGI
Official Full Name
membrane-spanning 4-domains, subfamily A, member 4Cprovided by MGI
Primary source
MGI:MGI:1927656
See related
Ensembl:ENSMUSG00000024675 AllianceGenome:MGI:1927656
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ms4a9; 5830413L19Rik
Summary
Predicted to be located in Golgi apparatus; endoplasmic reticulum; and plasma membrane raft. Orthologous to human MS4A4A (membrane spanning 4-domains A4A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 3.3), mammary gland adult (RPKM 2.1) and 7 other tissues See more
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Genomic context

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Location:
19 A; 19 8.44 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11382081..11404610)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11404717..11427246)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene membrane-spanning 4-domains, subfamily A, member 7 Neighboring gene membrane-spanning 4-domains, subfamily A, member 4A Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene membrane-spanning 4-domains, subfamily A, member 4B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Ishibashi K, et al. Gene, 2001 Feb 7. PMID 11245982
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Liang Y, et al. Genomics, 2001 Mar 1. PMID 11401424
  3. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
  4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
membrane-spanning 4-domains, subfamily A, member 4C
Names
membrane-spanning 4-domains, subfamily A, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029499.3 → NP_083775.1  membrane-spanning 4-domains, subfamily A, member 4C

    See identical proteins and their annotated locations for NP_083775.1

    Status: VALIDATED

    Source sequence(s)
    AC125406, AK151045
    Consensus CDS
    CCDS29599.1
    UniProtKB/TrEMBL
    Q3U5N6, Q99N06, Q9D3F6
    Related
    ENSMUSP00000072512.4, ENSMUST00000072729.10
    Conserved Domains (1) summary
    pfam04103
    Location:43 → 171
    CD20; CD20-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    11382081..11404610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527250.2 → XP_006527313.1  membrane-spanning 4-domains, subfamily A, member 4C isoform X1

    See identical proteins and their annotated locations for XP_006527313.1

    UniProtKB/TrEMBL
    Q3U5N6, Q99N06, Q9D3F6
    Conserved Domains (1) summary
    pfam04103
    Location:43 → 171
    CD20; CD20-like family

  2. XM_006527251.4 → XP_006527314.1  membrane-spanning 4-domains, subfamily A, member 4C isoform X1

    See identical proteins and their annotated locations for XP_006527314.1

    UniProtKB/TrEMBL
    Q3U5N6, Q99N06, Q9D3F6
    Related
    ENSMUSP00000113130.2, ENSMUST00000119366.2
    Conserved Domains (1) summary
    pfam04103
    Location:43 → 171
    CD20; CD20-like family

  3. XM_017318270.2 → XP_017173759.1  membrane-spanning 4-domains, subfamily A, member 4C isoform X2

    Conserved Domains (1) summary
    pfam04103
    Location:10 → 76
    CD20; CD20-like family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022429.1: Suppressed sequence

    Description
    NM_022429.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

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