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RAP1BL RAP1B like (pseudogene) [ Homo sapiens (human) ]

Gene ID: 643752, updated on 23-Nov-2023

Summary

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Official Symbol
RAP1BLprovided by HGNC
Official Full Name
RAP1B like (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:55079
See related
AllianceGenome:HGNC:55079
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Rap protein signal transduction; cellular response to cAMP; and negative regulation of synaptic vesicle exocytosis. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
5q13.3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (76173091..76174354, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (76654581..76655844, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (75465910..75470179, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:75378019-75378572 Neighboring gene MPRA-validated peak5296 silencer Neighboring gene SV2C antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:75566225-75566726 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:75566727-75567226 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 4 Neighboring gene programmed cell death 5 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HRap1B-retro: a novel human processed rap1B gene blurs the picture? Zemojtel T, et al. Leukemia, 2006 Jan. PMID 16307016
  2. Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity. Zemojtel T, et al. BMC Evol Biol, 2010 Feb 19. PMID 20170508, Free PMC Article
  3. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022
  4. Proteome analysis of the circadian clock protein PERIOD2. Gul H, et al. Proteins, 2022 Jun. PMID 35122331
  5. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Bett JS, et al. Biochem J, 2013 Apr 15. PMID 23398456, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • RAP1B, member of RAS oncogene family pseudogene
  • Rap1B-retro
  • Ras-related protein Rap-1b-like protein
  • hCG1757335
  • hRap1B-retro

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Rap protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to cAMP IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012429.2 

    Range
    101..1364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    76173091..76174354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    76654581..76655844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001089704.3: Suppressed sequence

    Description
    NM_001089704.3: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NIZ1.1 GenPept UniProtKB/Swiss-Prot:A6NIZ1

Gene LinkOut

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Chemical Information
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