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Fndc4 fibronectin type III domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 64339, updated on 21-Apr-2024

Summary

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Official Symbol
Fndc4provided by MGI
Official Full Name
fibronectin type III domain containing 4provided by MGI
Primary source
MGI:MGI:1917195
See related
Ensembl:ENSMUSG00000038552 AllianceGenome:MGI:1917195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FRCP1; Fnmp1; 2810430J06Rik; 6330410H20Rik
Summary
Involved in negative regulation of inflammatory response. Located in endoplasmic reticulum; extracellular space; and plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FNDC4 (fibronectin type III domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 37.1), CNS E18 (RPKM 36.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B1; 5 17.27 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31449589..31453279, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31292242..31295935, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene keratinocyte associated protein 3 Neighboring gene intraflagellar transport 172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31593577-31593686 Neighboring gene glucokinase regulatory protein Neighboring gene STARR-seq mESC enhancer starr_12769 Neighboring gene predicted gene, 19457

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibronectin type III domain containing four promotes differentiation of C2C12 through the Wnt/β-catenin signaling pathway. Li J, et al. FASEB J, 2020 Jun. PMID 32298013
  2. FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression. Lv ZT, et al. Biomed Res Int, 2018. PMID 29977911, Free PMC Article
  3. Fibronectin Type III Domain Containing 4 attenuates hyperlipidemia-induced insulin resistance via suppression of inflammation and ER stress through HO-1 expression in adipocytes. Lee W, et al. Biochem Biophys Res Commun, 2018 Jul 7. PMID 29787756
  4. Expression patterns of Neil3 during embryonic brain development and neoplasia. Hildrestrand GA, et al. BMC Neurosci, 2009 May 9. PMID 19426544, Free PMC Article
  5. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Georgiadi A, et al. Nat Commun, 2021 May 20. PMID 34016966, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
    Title: Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
  2. Fibronectin type III domain containing four promotes differentiation of C2C12 through the Wnt/beta-catenin signaling pathway.
    Title: Fibronectin type III domain containing four promotes differentiation of C2C12 through the Wnt/β-catenin signaling pathway.
  3. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10
    Title: FNDC4 Inhibits RANKL-Induced Osteoclast Formation by Suppressing NF-κB Activation and CXCL10 Expression.
  4. The HO-1-mediated pathway is involved in the suppressive effects of FNDC4 on inflammation and insulin resistance.
    Title: Fibronectin Type III Domain Containing 4 attenuates hyperlipidemia-induced insulin resistance via suppression of inflammation and ER stress through HO-1 expression in adipocytes.
  5. FNDC4 as a factor with direct therapeutic potential in inflammatory bowel disease and possibly other inflammatory diseases.
    Title: FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fibronectin type III domain-containing protein 4
Names
fibronectin type III repeat containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356945.2 → NP_001343874.1  fibronectin type III domain-containing protein 4 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Conserved Domains (1) summary
    cd00063
    Location:43 → 133
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001356946.2 → NP_001343875.1  fibronectin type III domain-containing protein 4 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS19181.1
    UniProtKB/Swiss-Prot
    Q3TR08, Q810E5, Q9CYY4
    UniProtKB/TrEMBL
    A0A0J9YUI2, B9EI95
    Related
    ENSMUSP00000047185.8, ENSMUST00000041266.11
    Conserved Domains (1) summary
    cd00063
    Location:43 → 133
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_001378890.1 → NP_001365819.1  fibronectin type III domain-containing protein 4 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Conserved Domains (1) summary
    cd00063
    Location:43 → 133
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. NM_022424.7 → NP_071869.2  fibronectin type III domain-containing protein 4 isoform b precursor

    See identical proteins and their annotated locations for NP_071869.2

    Status: VALIDATED

    Source sequence(s)
    AC114619
    Consensus CDS
    CCDS19181.1
    UniProtKB/Swiss-Prot
    Q3TR08, Q810E5, Q9CYY4
    UniProtKB/TrEMBL
    A0A0J9YUI2, B9EI95
    Related
    ENSMUSP00000127404.2, ENSMUST00000172435.8
    Conserved Domains (1) summary
    cd00063
    Location:43 → 133
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31449589..31453279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TR08.1 GenPept UniProtKB/Swiss-Prot:Q3TR08

Gene LinkOut

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