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LINC00452 long intergenic non-protein coding RNA 452 [ Homo sapiens (human) ]

Gene ID: 643365, updated on 5-Mar-2024

Summary

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Official Symbol
LINC00452provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 452provided by HGNC
Primary source
HGNC:HGNC:42800
See related
Ensembl:ENSG00000229373 AllianceGenome:HGNC:42800
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC00453
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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Location:
13q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113895103..113921317)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (113106573..113132138)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114598076..114624290)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114576933-114577480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114577481-114578027 Neighboring gene GAS6 divergent transcript Neighboring gene long intergenic non-protein coding RNA 454 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114616152-114617351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114622697-114623581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114638965-114639466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114639467-114639966 Neighboring gene chromosome 13 open reading frame 46 Neighboring gene SWI/SNF complex interacting GAS6 enhancer non-coding RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114748299-114748799 Neighboring gene RAS p21 protein activator 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114789740-114790579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114796667-114797608 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114801666-114802865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114804717-114805611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114812769-114813560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114813561-114814350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114829337-114829856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5554 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8054 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114838566-114839765 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114848666-114849865 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114852049-114853248 Neighboring gene RASA3 intronic transcript 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation. Yang J, et al. Aging (Albany NY), 2020 Nov 9. PMID 33168781, Free PMC Article
  2. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. Wang J, et al. Pharmacogenomics J, 2013 Jun. PMID 22491018
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
    Title: LINC00452 promotes ovarian carcinogenesis through increasing ROCK1 by sponging miR-501-3p and suppressing ubiquitin-mediated degradation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Other Names

  • long intergenic non-protein coding RNA 453

Clone Names

  • FLJ44054

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_164112.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX072579
    Related
    ENST00000426859.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    113895103..113921317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    113106573..113132138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039767.1: Suppressed sequence

    Description
    NM_001039767.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

  2. NM_001278674.1: Suppressed sequence

    Description
    NM_001278674.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.

  3. NR_024609.1: Suppressed sequence

    Description
    NR_024609.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version

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