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FAM163B family with sequence similarity 163 member B [ Homo sapiens (human) ]

Gene ID: 642968, updated on 5-Mar-2024

Summary

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Official Symbol
FAM163Bprovided by HGNC
Official Full Name
family with sequence similarity 163 member Bprovided by HGNC
Primary source
HGNC:HGNC:33277
See related
Ensembl:ENSG00000196990 AllianceGenome:HGNC:33277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf166
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 9.7) and adrenal (RPKM 1.9) See more
Orthologs
mouse all
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Genomic context

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See FAM163B in Genome Data Viewer
Location:
9q34.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133577081..133609389, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145791075..145825393, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136442203..136474511, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136385034-136385534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136395091-136395596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136398691-136399232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136399233-136399772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136399773-136400314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136400855-136401396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136401937-136402476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136404277-136405008 Neighboring gene myomaker, myoblast fusion factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136405742-136406473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136407445-136407945 Neighboring gene ADAMTS like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136410411-136411066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136420460-136420962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136420963-136421464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136421967-136422468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136436438-136437078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136442732-136443347 Neighboring gene uncharacterized LOC124902296 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:136457531-136458030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136480627-136481226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136502750-136503485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136519605-136520404 Neighboring gene dopamine beta-hydroxylase Neighboring gene DBH antisense RNA 1 Neighboring gene SARDH intron CAGE-defined T cell enhancer Neighboring gene sarcosine dehydrogenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136550530-136551030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136576505-136577208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136580725-136581428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136581429-136582130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136592563-136593073

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Unknown genes, Cebelin and Cebelin-like, predominantly expressed in mouse brain. Miwa H, et al. Heliyon, 2018 Sep. PMID 30294689, Free PMC Article
  2. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Ivarsson Y, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550280, Free PMC Article
  3. Proteome-wide analysis of phospho-regulated PDZ domain interactions. Sundell GN, et al. Mol Syst Biol, 2018 Aug 20. PMID 30126976, Free PMC Article
  4. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM163B
Names
cebelin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080515.3 → NP_001073984.1  protein FAM163B

    See identical proteins and their annotated locations for NP_001073984.1

    Status: VALIDATED

    Source sequence(s)
    AC002101, BX629352
    Consensus CDS
    CCDS35171.1
    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
    Related
    ENSP00000501259.1, ENST00000673969.1
    Conserved Domains (1) summary
    pfam15069
    Location:1 → 165
    FAM163; FAM163 family

  2. NM_001371529.1 → NP_001358458.1  protein FAM163B

    Status: VALIDATED

    Source sequence(s)
    BX629352
    Consensus CDS
    CCDS35171.1
    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
    Related
    ENSP00000419867.1, ENST00000496132.2
    Conserved Domains (1) summary
    pfam15069
    Location:1 → 165
    FAM163; FAM163 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    133577081..133609389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423715.1 → XP_047279671.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  2. XM_047423714.1 → XP_047279670.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  3. XM_047423716.1 → XP_047279672.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  4. XM_047423718.1 → XP_047279674.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  5. XM_005272204.5 → XP_005272261.1  protein FAM163B isoform X1

    See identical proteins and their annotated locations for XP_005272261.1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
    Conserved Domains (1) summary
    pfam15069
    Location:1 → 165
    FAM163; FAM163 family

  6. XM_047423717.1 → XP_047279673.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  7. XM_017015017.2 → XP_016870506.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
    Conserved Domains (1) summary
    pfam15069
    Location:1 → 165
    FAM163; FAM163 family

  8. XM_011518912.3 → XP_011517214.1  protein FAM163B isoform X1

    See identical proteins and their annotated locations for XP_011517214.1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
    Conserved Domains (1) summary
    pfam15069
    Location:1 → 165
    FAM163; FAM163 family

  9. XM_006717233.4 → XP_006717296.1  protein FAM163B isoform X1

    See identical proteins and their annotated locations for XP_006717296.1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
    Conserved Domains (1) summary
    pfam15069
    Location:1 → 165
    FAM163; FAM163 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    145791075..145825393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363518.1 → XP_054219493.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  2. XM_054363517.1 → XP_054219492.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  3. XM_054363520.1 → XP_054219495.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  4. XM_054363521.1 → XP_054219496.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3

  5. XM_054363519.1 → XP_054219494.1  protein FAM163B isoform X1

    UniProtKB/Swiss-Prot
    B2RUZ5, P0C2L3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C2L3.1 GenPept UniProtKB/Swiss-Prot:P0C2L3

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