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Abhd8 abhydrolase domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 64296, updated on 5-Mar-2024

Summary

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Official Symbol
Abhd8provided by MGI
Official Full Name
abhydrolase domain containing 8provided by MGI
Primary source
MGI:MGI:1918946
See related
Ensembl:ENSMUSG00000007950 AllianceGenome:MGI:1918946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0910001L24Rik
Summary
Predicted to enable carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adrenal gland; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human ABHD8 (abhydrolase domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 112.6), testis adult (RPKM 107.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71909344..71917351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71456700..71464707, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1758 Neighboring gene STARR-positive B cell enhancer ABC_E9729 Neighboring gene predicted gene, 39193 Neighboring gene ankyrin repeat and LEM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6651 Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rapid and Integrative Discovery of Retina Regulatory Molecules. Albrecht NE, et al. Cell Rep, 2018 Aug 28. PMID 30157441, Free PMC Article
  2. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ABHD8
Names
abhydrolase domain-containing protein 8
alpha/beta hydrolase domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022419.3 → NP_071864.2  protein ABHD8

    See identical proteins and their annotated locations for NP_071864.2

    Status: VALIDATED

    Source sequence(s)
    AC127416, AK003090
    Consensus CDS
    CCDS40382.1
    UniProtKB/Swiss-Prot
    Q8R0P8, Q9DC79, Q9JMF5
    Related
    ENSMUSP00000008094.9, ENSMUST00000008094.10
    Conserved Domains (1) summary
    COG0596
    Location:149 → 408
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71909344..71917351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243705.1 → XP_030099565.1  protein ABHD8 isoform X1

    UniProtKB/Swiss-Prot
    Q8R0P8, Q9DC79, Q9JMF5
    Conserved Domains (1) summary
    COG0596
    Location:149 → 408
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. XM_036154226.1 → XP_036010119.1  protein ABHD8 isoform X1

    UniProtKB/Swiss-Prot
    Q8R0P8, Q9DC79, Q9JMF5
    Conserved Domains (1) summary
    COG0596
    Location:149 → 408
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0P8.1 GenPept UniProtKB/Swiss-Prot:Q8R0P8

Gene LinkOut

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