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Tmub1 transmembrane and ubiquitin-like domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 64295, updated on 11-Apr-2024

Summary

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Official Symbol
Tmub1provided by MGI
Official Full Name
transmembrane and ubiquitin-like domain containing 1provided by MGI
Primary source
MGI:MGI:1923764
See related
Ensembl:ENSMUSG00000028958 AllianceGenome:MGI:1923764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hops; 2010004O20Rik
Summary
Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in several cellular components, including cytoskeleton; endosome; and postsynaptic membrane. Predicted to be integral component of membrane. Orthologous to human TMUB1 (transmembrane and ubiquitin like domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 41.2), colon adult (RPKM 38.0) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 11.79 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24650461..24652859, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24445463..24447846, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333 Neighboring gene Fas-activated serine/threonine kinase Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene VISTA enhancer mm1191 Neighboring gene gastrulation brain homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional expression and localisation of HOPS/TMUB1 in mouse lens. Bartoli D, et al. Biosci Rep, 2021 Feb 26. PMID 33543240, Free PMC Article
  2. HOPS is an essential constituent of centrosome assembly. Pieroni S, et al. Cell Cycle, 2008 May 15. PMID 18418082
  3. Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis. Ferracchiato S, et al. Int J Mol Sci, 2021 Jul 2. PMID 34281239, Free PMC Article
  4. Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation. Fu H, et al. Cell Signal, 2019 Mar. PMID 30610893
  5. Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19 Arf network. Castelli M, et al. Oncogene, 2013 Jul 11. PMID 22890319

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional expression and localisation of HOPS/TMUB1 in mouse lens.
    Title: Functional expression and localisation of HOPS/TMUB1 in mouse lens.
  2. Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis.
    Title: Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis.
  3. HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.
    Title: HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response through the modulation of TRAF6.
  4. HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis.
    Title: HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent mitochondrial apoptosis.
  5. The results of this study suggest that Tmub1 is an important negative regulator of hepatocyte proliferation in liver regeneration through STAT3 (signal transducer and activator of transcription 3 protein) signaling.
    Title: Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation.
  6. HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm.
    Title: Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system.
  7. HOPS acts as a functional bridge in the interaction between NPM and p19(Arf)
    Title: Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19 Arf network.
  8. results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG
    Title: Transmembrane and ubiquitin-like domain containing 1 (Tmub1) regulates locomotor activity and wakefulness in mice and interacts with CAMLG.
  9. transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GluR2 to the plasma membrane
    Title: Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors.
  10. HOPS is involved in centrosome assembly and maintenance.
    Title: HOPS is an essential constituent of centrosome assembly.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and ubiquitin-like domain-containing protein 1
Names
hepatocyte odd protein shuttling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022418.3 → NP_071863.1  transmembrane and ubiquitin-like domain-containing protein 1

    See identical proteins and their annotated locations for NP_071863.1

    Status: VALIDATED

    Source sequence(s)
    AB030183, BB871344
    Consensus CDS
    CCDS19121.1
    UniProtKB/Swiss-Prot
    Q53AQ3, Q9JMG3
    UniProtKB/TrEMBL
    E9QN77
    Related
    ENSMUSP00000030799.9, ENSMUST00000030799.15
    Conserved Domains (1) summary
    cd17131
    Location:101 → 171
    Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24650461..24652859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535786.3 → XP_006535849.1  transmembrane and ubiquitin-like domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006535849.1

    UniProtKB/Swiss-Prot
    Q53AQ3, Q9JMG3
    UniProtKB/TrEMBL
    E9QN77
    Conserved Domains (1) summary
    cd17131
    Location:101 → 171
    Ubl_TMUB1; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JMG3.1 GenPept UniProtKB/Swiss-Prot:Q9JMG3

Gene LinkOut

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